目的 查明羊场发生不明原因死亡的病因，为羊场类似疾病的诊断防控提供参考。 方法 2023年10月，湖北省某羊场报告发生山羊不明原因死亡，患羊临床症状主要表现为体温升高至41 ℃、腹泻、流脓鼻涕、咳嗽等。为查明发病原因，笔者开展调查采样和实验室检测。现场调查，对2只典型症状的病死羔羊进行剖检；采集患病山羊血清20份、口鼻拭子20份、羊舍地面环境样本6份、病死羊肺脏组织2份，开展布病抗体、小反刍兽疫病原、口蹄疫病原、山羊传染性胸膜肺炎病原和寄生虫病实验室检测。 结果 在剖检中发现传染性胸膜肺炎的典型病理特征；实验室检测结果显示，布病抗体、小反刍兽疫病原和口蹄疫病原均为阴性，检出1份肺脏样品为传染性胸膜肺炎阳性，镜检发现6份粪便样品中均存在大量寄生虫体及虫卵。 结论 综合诊断，该场确诊感染寄生虫病，并继发感染山羊传染性胸膜肺炎。

Objectives The causes of unknown mortality in a goat farm were identified to provide reference for the diagnosis and the control and prevention of similar diseases in goat farms. Methods A goat farm in Hubei Province reported an unexplained death of a goat in October 2023. The clinical symptoms of the affected goats mainly included an increase in body temperature to 41 ℃, diarrhea, runny nose, cough, etc. Authors conducted sampling for investigation and laboratory testing to identify the cause of the disease. On-site investigation was conducted and two deceased lambs with typical symptoms were subjected to necropsy. 20 blood sera, 20 nasal swabs, 6 samples of the ground environment in the sheep shed, and 2 lung tissue samples were collected from diseased goats for laboratory testing of antibodies against brucellosis, Peste des Petits Ruminants (PPR) pathogen, foot-and-mouth disease (FMD) pathogen, caprine contagious pleuropneumonia (CPP) pathogen, and parasitosis. Results Typical pathological features of contagious pleuropneumonia were found during necropsy. The results of laboratory testing showed that the antibodies against brucellosis, PPR pathogen, and FMD pathogen were all negative. One lung tissue sample was detected as positive for CPP. The results of microscopic examination showed that there were a large number of parasites and eggs of worms in 6 fecal samples. Conclusions The comprehensive diagnosis confirmed that there was the infection of parasitosis and secondary infection of contagious pleuropneumonia in goats from this goat farm.