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Mechanisms of Drug Resistance Associated with Acinetobacter baumannii and Treatment Progress
Xinyue SHI, Dingyu ZHANG
PDF(812 KB)
PDF(812 KB)
Mechanisms of Drug Resistance Associated with Acinetobacter baumannii and Treatment Progress
Acinetobacter baumannii, a prevalent multidrug-resistant pathogen in Intensive Care Units, poses a significant threat to critically ill patients. With limited effective antibiotic options, Acinetobacter baumannii infections lead to high infection and mortality rates. Its resistance mechanisms include efflux pump activity, target mutations, activation of antibiotic-modifying enzymes, biofilm formation, and quorum sensing system regulation. Recognizing Acinetobacter as a priority for antibiotic development, this article emphasized the urgency of developing new antibiotics. It concentrated on novel antibiotic development, exploring non-traditional antimicrobial agents, potential vaccines, and advancing multimodal infection control strategies, serving as both preventive and alternative therapeutic responses to the escalating challenge of antibiotic resistance.
Acinetobacter baumannii / Drug resistance mechanism / Multi-mode sensing
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