Current Status and Prospects of Clinical Cure for Chronic Hepatitis B

Yuchen PENG, Xiaoping WU

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Journal of Southwest Medical University ›› 2025, Vol. 48 ›› Issue (1) : 27-31. DOI: 10.3969/j.issn.2096-3351.2025.01.006
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Current Status and Prospects of Clinical Cure for Chronic Hepatitis B

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Abstract

Chronic hepatitis B is a progressive disease that leads to a significant number of deaths each year due to cirrhosis and hepatocellular carcinoma. In recent years, with the deepening understanding of the mechanisms of Hepatitis B virus infection, advancements in different transformation strategies for nucleos(t)ide analogs and long-acting interferons, and the development of new drugs, a cure for hepatitis B has become an achievable goal. This paper reviewed the concept of clinical cure for hepatitis B, its historical development, potential mechanisms, the current treatment landscape, and the latest progress in new drug development. The challenges encountered in the process of curing hepatitis B and directions for future efforts were also discussed, providing a reference for clinical research and practice.

Key words

Chronic hepatitis B / Clinical cure / Treatment strategies / Nucleos(t)ide analogs / Interferon

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Yuchen PENG , Xiaoping WU. Current Status and Prospects of Clinical Cure for Chronic Hepatitis B. Journal of Southwest Medical University. 2025, 48(1): 27-31 https://doi.org/10.3969/j.issn.2096-3351.2025.01.006

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