B、N和F共掺杂的新型碳点对硝唑类抗生素的检测（英文）

贾燕春, 胡军辉, 宋胜梅, 双少敏, 董川

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中国高校科技期刊信息汇聚平台
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山西大学学报(自然科学版) ›› 2025, Vol. 48 ›› Issue (03) : 578-588. DOI: 10.13451/j.sxu.ns.2024167

B、N和F共掺杂的新型碳点对硝唑类抗生素的检测（英文）

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摘要

以氟硼酸钠、柠檬酸、乙胺和乙腈为前驱体，通过一步溶剂热法制备了硼、氮、氟共掺杂的蓝色荧光碳点（Blue Fluorescent Carbon Dots， BNF-CDs），分别利用透射电子显微镜、傅里叶变换红外光谱、X射线光电子能谱、紫外可见吸收和荧光光谱等对合成的BNF-CDs进行了结构、形貌及光学性能表征。结果表明，BNF-CDs具有稳定优异的光学性能，荧光量子产率高达65.9%。基于内滤作用，硝唑类抗生素可有效猝灭BNF-CDs的荧光，为甲硝唑类抗生素（Metronidazole， MTR）、奥硝唑类抗生素（Ornidazole， ORN）和替硝唑类抗生素（Tinidazole， TIN）的检测提供了一种新的荧光检测方法，并建立了相应的硝基咪唑类抗生素的检测曲线，线性范围分别为6 ~250 μmol/L、3.6 ~189 μmol/L和3.6 ~295 μmol/L，检出限分别为16 nmol/L、35 nmol/L、71 nmol/L。此外，对实际样品中MTR、ORN和TIN的测定也取得了满意的回收率（96.4%~105.8%），表明了该方法潜在的应用前景。

Abstract

Blue fluorescent carbon dots (BNF-CDs) co-doped with boron, nitrogen and fluorine were prepared by a one-step solvothermal method using sodium fluoroborate, citric acid, ethylamine and acetonitrile as precursors. Herein, the structure, morphology and optical properties of BNF-CDs were characterized by transmission electron microscopy, Fourier transform infrared spectrometer, X-ray photoelectron spectroscopy, UV-Vis absorption and fluorescence spectroscopy, respectively. The results illustrated that the BNF-CDs have stable and excellent optical properties with a high fluorescence quantum yield of 65.9%. Based on the internal filtration effect between BNF-CDs and nitroimidazole antibiotics, the fluorescence of BNF-CDs can be effectively quenched. This phenomenon provides a novel fluorescence method for the determination of metronidazole (MTR), ornidazole (ORN) and tinidazole (TIN), and the corresponding detection curves for these nitroimidazole antibiotics were established, with linear ranges of 6-250 μmol/L for MTR, 3.6-189 μmol/L for ORN and 3.6-295 μmol/L for TIN. The detection limits were found to be 16 nmol/L, 35 nmol/L and 71 nmol/L, respectively. In addition, satisfactory recovery rates (rangihg from 96.4% to 105.8%) have been achieved for determination of MTR, ORN and TIN in actual samples,which indicates its potential application in the future.

关键词

硝唑类抗生素 / 碳点 / 内滤效应 / 多功能检测

Key words

nitroimidazole antibiotics / carbon dots / internal filtration effect / multifunctional detection

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贾燕春 , 胡军辉 , 宋胜梅 , 等. B、N和F共掺杂的新型碳点对硝唑类抗生素的检测. 山西大学学报(自然科学版). 2025, 48(03): 578-588 https://doi.org/10.13451/j.sxu.ns.2024167

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基金

国家自然科学基金(22274090)
山西省经方扶阳重点实验室(202104010910011)
山西省基础研究项目(202203021221026)
山西省专利转化项目(202306012)

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