Research Progress of Preparation of Antibacterial Polylactic Acid Nanofiber Membrane by Electrospinning

FENG Xiaolin, LI Xuming

PDF(1085 KB)
PDF(1085 KB)
Plastics Science and Technology ›› 2025, Vol. 53 ›› Issue (03) : 176-180. DOI: 10.15925/j.cnki.issn1005-3360.2025.03.031
Review

Research Progress of Preparation of Antibacterial Polylactic Acid Nanofiber Membrane by Electrospinning

Author information +
History +

Abstract

Polylactic acid (PLA) is a biodegradable and environmentally friendly material. With the increasing awareness of environmental protection and safety among people, research and development of the antibacterial properties of PLA have attracted more and more attention. The article reviews the impact of single-needle electrospinning, coaxial electrospinning, and emulsion electrospinning on the antibacterial properties of PLA nanofiber membranes. It introduces the types of antibacterial PLA nanofiber membranes and their antibacterial mechanisms, and summarizes the applications of antibacterial PLA nanofiber membranes in medical dressings, packaging, and filtration. The results show that different electrospinning techniques have a certain impact on the antibacterial properties of PLA nanofiber membranes. Among them, coaxial electrospinning and emulsion electrospinning can mitigate the drawback of burst release of antibacterial agents, showing good application prospects. Nanofiber membranes prepared from different types of antibacterial agents and PLA through electrospinning all exhibit good antibacterial properties, but they also have certain drawbacks and can be selected according to specific needs. The production efficiency of electrospinning technology is relatively low and cannot be scaled up for industrial production. Therefore, further in-depth research on electrospinning technology is needed in the future to continuously improve its production efficiency. In addition, the reusability of antibacterial PLA nanofiber membranes and the durability of their antibacterial properties still need to be further enhanced.

Key words

Polylactic acid / Electrospinning / Antibacterial property

Cite this article

Download Citations
FENG Xiaolin , LI Xuming. Research Progress of Preparation of Antibacterial Polylactic Acid Nanofiber Membrane by Electrospinning. Plastics Science and Technology. 2025, 53(03): 176-180 https://doi.org/10.15925/j.cnki.issn1005-3360.2025.03.031

References

1
王改改,刘让同,徐薇仪,等.核壳结构多孔纳米纤维膜的制备及油水分离性能研究[J].化工新型材料,2024,52(5):1-11.
2
WU J H, HU T G, WANG H, et al. Electrospinning of PLA nanofibers: Recent advances and its potential application for food packaging[J]. Journal of Agricultural and Food Chemistry, 2022, 70(27): 8207-8221.
3
ERTEK D A, SANLI N O, MENCELOGLU Y Z, et al. Environmentally friendly, antibacterial materials from recycled keratin incorporated electrospun PLA films with tunable properties[J]. Eurpean Polymer Journal, 2023, 185: 111804.
4
AHMADIAN S, GHORBANI M, MAHMOODZADEH F. Silver sulfadiazine-loaded electrospun ethyl cellulose/polylactic acid/collagen nanofibrous mats with antibacterial properties for wound healing[J]. International Journal of Biological Macromolecules, 2020, 162: 1555-1565.
5
WU J, LIU S Q, WU G H, et al. Preparation and properties of polylactic acid (PLA) antibacterial nanofiber membrane with Ag@TP composite antibacterial agent[J]. the Journal of the Textile Institute, 2023, 114: 1887-1897.
6
MONFARED M, TAGHIZADEH S, ZARE-HOSEINABADI A, et al. Emerging frontiers in drug release control by core-shell nanofibers: A review[J]. Drug Metab Rev, 2019, 51(4): 589-611.
7
郭文利,任晓龙,陈江义.多针头静电纺丝电场分布改善及仿真分析[J].西安科技大学学报,2022,42(4):833-840.
8
李思程,张岑,谌迪,等.同轴静电纺丝多级结构纳米纤维的研究进展及其在食品领域的应用现状[J].食品科学,2024,45(13):300-311.
9
HE C L, HUANG Z M, HAN X J. Fabrication of drug-loaded electrospun aligned fibrous threads for suture applications[J]. Journal of Biomedical Materials Research Part A, 2009, 89A(1): 80-95.
10
张菂,刘淑强,武捷,等.同轴静电纺抗菌PLA纳米纤维膜的制备及其性能[J].棉纺织技术,2024,52(8):8-12.
11
PHAECHAMUD T, CHITRATTHA S. Pore formation mechanism of porous poly(DL-lactic acid) matrix membrane[J]. Materials Science and Engineering: C, 2016, 61: 744-752.
12
CHEN X, LI H H, LU W P, et al. Antibacterial porous coaxial drug-carrying nanofibers for sustained drug-releasing applications[J]. Nanomaterials, 2021, 11(5): 1316.
13
YAN X, XU B, XIA C M, et al. Dual drug-loaded core-shell nanofibers membranes via emulsion electrospinning and their controllable sustained release property[J]. Journal of Drug Delivery Science Technology, 2023, 88: 104909.
14
ZHANG C, FENG F Q, ZHANG H. Emulsion electrospinning: Fundamentals, food applications and prospects[J]. Trends Food Science & Technology, 2018, 80: 175-186.
15
WEN P, WEN Y, ZONG M H, et al. Encapsulation of bioactive compound in electrospun fibers and its potential application[J]. Journal of Agricultral & Food Chemistry, 2017, 65: 9161-9179.
16
刘毅,刘喻,李庭晓,等.乳液静电纺载药PLA纳米纤维的制备及缓释性能[J].上海纺织科技,2023,51(11):26-30.
17
ZHANG W, LIU H M, YAN L, et al. Combining emulsion electrospinning with surface functionalization to fabricate multistructural PLA/CS@ZIF-8 nanofiber membranes toward pH-responsive dual drug delivery[J]. International Journal of Biological Macromolecules, 2023, 253: 12.
18
王栋,董永明.纺织品抗菌剂的种类及其应用[J].国际纺织导报,2023,51(6):13-15.
19
GANGADHARAN D, HARSHVARDAN K, GNANASEKAR G, et al. Polymeric microspheres containing silver nanoparticles as a bactericidal agent for water disinfection[J]. Water Research, 2010, 44: 5481-5487.
20
WU Z C, ZHANG Z J, SONG X L, et al. A silver nanoparticles-polylactic acid microspheres/polylactic acid-thermoplastic polyurethane nanofibers hierarchical antibacterial film[J]. Industrial Crops Products, 2024, 207: 11.
21
SHE P, LI S M, LI X J, et al. Photocatalytic antibacterial agents based on inorganic semiconductor nanomaterials: A review[J]. Nanoscale, 2024, 16: 4961-4973.
22
LV H L, XIA X M, SUN S, et al. Polylactic acid electrospun membrane loaded with cerium nitrogen co-doped titanium dioxide for visible light-triggered antibacterial photocatalytic therapy[J]. Frontiers Microbiology, 2024, 15: 14.
23
DING J, DWIBEDI V, HUANG H T, et al. Preparation and antibacterial mechanism of cinnamaldehyde/tea polyphenol/polylactic acid coaxial nanofiber films with zinc oxide sol to Shewanella putrefaciens[J]. International Journal of Biological Macromolecules, 2023, 237: 10.
24
SHAO W L, NIU J Y, HAN R K, et al. Electrospun multiscale poly(lactic acid) nanofiber membranes with a synergistic antibacterial effect for air-filtration applications[J]. ACS Applied Polymer Materals Journal, 2023, 5: 9632-9641.
25
YANG S S, SHANG P P, ZHANG K, et al. PBAT/PLA food packaging film containing sodium dehydroacetate-loaded diatomite as an antibacterial agent: Fabrication, water-gas regulation and long-acting antimicrobial mechanism[J]. Food Chemistry, 2024, 446: 11.
26
VIDAL C P, VELáSQUEZ E, GALOTTO M J, et al. Development of an antibacterial coaxial bionanocomposite based on electrospun core/shell fibers loaded with ethyl lauroyl arginate and cellulose nanocrystals for active food packaging[J]. Food Packaging Shelf Life, 2022, 31: 9.
27
YI S M, ZHU J L, FU L L, et al. Tea polyphenols inhibit Pseudomonas aeruginosa through damage to the cell membrane[J]. International Journal of Food Microbiology, 2010, 144: 111-117.
28
WILLIAMS L, HATTON F L, RIGHETTI M C, et al. Investigating how the properties of electrospun poly(lactic acid) fibres loaded with the essential oil limonene evolve over time under different storage conditions[J]. Polymers, 2024, 16: 15.
29
YIN J, XU L, AHMED A. Batch preparation and characterization of electrospun porous polylactic acid-based nanofiber membranes for antibacterial wound dressing[J]. Advanced Fiber Materials, 2022, 4: 832-844.
30
BI H Y, FENG T Y, LI B B, et al. In vitro and in vivo comparison study of electrospun pla and pla/pva/sa fiber membranes for wound healing[J]. Polymers, 2020, 12(4): 839.
31
GE J, HAN D B, LI S Z, et al. Electrospun membrane of PLA/calendula with improved UV protection and stable filtration performance[J]. Separation and Purification Technology, 2024, 344: 12.
32
刘云春,朱平,张甜甜,等.抗菌性聚乳酸复合膜的制备和性能研究进展[J].塑料科技,2024,52(2):119-123.
33
滕桂香,杨怡凡,侯苏童,等.一步法制备PLA/PDA/Ag多孔抗菌纳米纤维膜及其促进伤口愈合作用研究[J].材料导报,2023,37(18):244-249.
34
LIU C Y, DU G C, GUO Q Q, et al. Fabrication and characterization of polylactic acid electrospun wound dressing modified with polyethylene glycol, rosmarinic acid and graphite oxide[J]. Nanomaterials, 2023, 13: 2000.
35
HAJIKHANI M, EMAM-DJOMEH Z, ASKARI G. Fabrication and characterization of mucoadhesive bioplastic patch via coaxial polylactic acid (PLA) based electrospun nanofibers with antimicrobial and wound healing application[J]. International Journal of Biological Macromolecules, 2021, 172: 143-153.
36
WANG H D, DONG Y Y, QIU W Q, et al. Development of slow release antibacterial polylactic acid bilayer active film with different distributions of clove essential oil and its application for snakehead (Channa argus) preservation[J]. Food Control, 2024, 162: 110473.
37
ZHENG H, CHEN L, LIU T H, et al. Poly-(lactic acid) composite films comprising carvacrol and cellulose nanocrystal-zinc oxide with synergistic antibacterial effects[J]. International Journal of Biological Macromolecules, 2024, 266: 10.
38
LIAO M J, PAN Y, FU X W, et al. Electrospun polylactic acid nanofiber film modified by silver oxide deposited on hemp fibers for antibacterial fruit packaging[J]. International Journal of Biological Macromolecules, 2023, 253: 17.
39
LI T, LIU Y X, QIN Q X, et al. Development of electrospun films enriched with ethyl lauroyl arginate as novel antimicrobial food packaging materials for fresh strawberry preservation[J]. Food Control, 2021, 130: 108371.
40
LIN M G, SHEN J L, QIAN Q A, et al. Fabrication of poly(lactic acid)@TiO2 electrospun membrane decorated with metal-organic frameworks for efficient air filtration and bacteriostasis[J]. Polymers, 2024, 16(7): 889.
41
LIANG C Y, LI J Q, CHEN Y Y, et al. Self-charging, breathable, and antibacterial poly(lactic acid) nanofibrous air filters by surface engineering of ultrasmall electroactive nanohybrids[J]. ACS Applied Materials & Interfaces, 2023, 15: 57636-57648.

Comments

PDF(1085 KB)

Accesses

Citation

Detail

Sections
Recommended

/