Based on the idea of origami, mechanical origami meta-materials can realize the special mechanical behaviour at the apparent material level by designing ingenious characteristic structures. To further integrate the performance advantages of origami and auxetic meta-materials, a novel multi-directional auxetic origami meta-material (AOMM) inspired by the origami paradigm was designed. Based on the load-bearing deformation mechanism of the stationary structure, the negative Poisson's ratio effect of the multi-directional AOMM was analyzed, the theoretical models of relative density, folding efficiency, equivalent elastic constitutivity and load plateau were established, and the influence law of geometric parameters on the folding load was revealed by the surface response. The multi-directional AOMM specimen was 3D printed using thermoplastic polyurethane (TPU) as the base material, and the deformation, load bearing and energy absorption characteristics were analyzed by quasi-static compression experiment. The results show that TPU AOMM has a certain shape recovery ability, a negative Poisson's ratio effect and a stable energy absorption plateau, and the theoretical values of the threshold strain entering load plateau and the relative density are in good agreement with the experimental results. The present research results can provide a reference for the design and application of auxetic origami meta-materials.