The article used sebacic acid and meta phenylenediamine as raw materials, and explored the synthesis process of nylon MXD10 through high-temperature and high-pressure melt polymerization. On this basis, the performance of the synthesized semi-aromatic nylon MXD10 was characterized. The structure of nylon MXD10 was analyzed using Fourier transform infrared spectroscopy. The thermal properties of nylon MXD10 were analyzed by differential scanning calorimetry and thermogravimetric analyzer. The results showed that the melting temperature and crystallization temperature of the synthesized nylon MXD10 were 175 °C and 117 °C, respectively. Thermal decomposition was a one-step decomposition method. Non isothermal crystallization kinetics analysis was also conducted on nylon MXD10, and the non isothermal crystallization kinetics of semi-aromatic nylon MXD10 were studied comprehensively through the Jeziorny equation and Mo Zhishen method. The results indicate that the crystal growth of semi-aromatic nylon MXD10 is two-dimensional, and the crystallization temperature decreases with the increase of cooling rate. The activation energy is -981.625 kJ/mol。