Study on the Migration Properties of Ultraviolet Absorbent UV-P in Light-Resistant TPU Infusion Device

CUI Ping, CAO Qing-feng, DING Yi -mei

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Plastics Science and Technology ›› 2024, Vol. 52 ›› Issue (08) : 126-131. DOI: 10.15925/j.cnki.issn1005-3360.2024.08.025
Physical and Chemical Tests

Study on the Migration Properties of Ultraviolet Absorbent UV-P in Light-Resistant TPU Infusion Device

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Abstract

This paper established a high performance liquid chromatography (HPLC) method for the determination of ultraviolet absorber UV-P in an light resistant thermoplastic polyurethane infusion device, and to carry out the research on the dissolution of ultraviolet absorber UV-P from disposable TPU infusion device. Six different types of injections were used to simulate the clinical application conditions, and after infusion with a light resistant TPU infusion device, they were analyzed by high-performance liquid chromatography. Kromasil C18 column was adopted, the mobile phase consisted of methanol-water (90∶10), the detection wavelength was 339 nm. The resuls show that calibration curves of UV-P are linear over the range of 0.061 4~1.638 0 mg/L (r=0.999 9), the average recoveries are both betwen 97.91% and 101.10%, the relative standard deviation is less than 2%, the signal-to-noise ratio is greater than 3, and the values of quantitation limit is 0.020 48 mg/L.The method is sensitive and good repeatability, which is suitable for the detection of UV-P dissolution in TPU infusion device.

Key words

Light-resistant thermoplastic polyurethane infusion device / Ultraviolet absorber UV-P / Dissolving out / HPLC

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CUI Ping , CAO Qing-feng , DING Yi -mei. Study on the Migration Properties of Ultraviolet Absorbent UV-P in Light-Resistant TPU Infusion Device. Plastics Science and Technology. 2024, 52(08): 126-131 https://doi.org/10.15925/j.cnki.issn1005-3360.2024.08.025

References

1
李晶婷,刘维峰,杨文月.药品避光、避光输注和药品光毒性[J].临床合理用药杂志,2019,12(14):179-180.
2
谭志美,郑春茂,王安发,等.临床常见静脉输注用抗肿瘤药物的输液器选择[J].肿瘤药学,2022,12(3):400-408.
3
凌浩青,姚颖.避光输液器加避光袋预防左氧氟沙星所致光敏反应的体会[J].中国社区医师,2016,32(3):129-130.
4
李胜南,李洪庆,张翠玲.研究喹诺酮类药物输液时使用避光式输液器的体会[J].中西医结合心血管病电子杂志,2019,7(5):194.
5
焦西斌,范要民,路丹.一次性避光输液器避光性能的研究[J].塑料助剂,2024(1):36-39.
6
颜林,方旻,黄梓为,等.一次性使用精密过滤避光输液器中颜料黄83的迁移溶出研究[J].塑料包装,2018,28(4):53-56.
7
屈文佳.医疗器械中增塑剂溶出与迁移带来的安全隐患[J].塑料助剂,2023(2):65-68.
8
傅星,葛雪松.克林霉素磷酸酯注射液对一次性输液器中邻苯二甲酸二(2-乙基)己酯的溶出研究[J].中国药师,2021,24(12):2274-2276.
9
黄元礼,王安琪,柯林楠,等.PVC一次性输液器中DEHP和TOTM增塑剂溶出量对比[J].北京生物医学工程,2015,34(2):161-165, 174.
10
张凤兰,张芳芳,顾维钧.PVC输液器中偏苯三酸三辛酯向脂肪乳注射液中迁移量的HPLC法测定[J].海峡药学,2022(2):45-47.
11
张凤兰,张芳芳,王蓉佳.气相色谱-质谱法测定镇痛泵中增塑剂环己烷1,2-二甲酸二异壬基酯迁移量[J].化学分析计量,2024,33(3):70-74.
12
王悦,金祥飞,周新宇,等.PVC输液器中环己酮和增塑剂ATBC的迁移性质研究[J].塑料工业,2016,44(7):84-87.
13
刘颖玲,吴长伟,翟永利,等.PVC一次性使用输液器中可沥滤物研究[J].分析仪器,2021(1):33-41.
14
苏欣,操敏,王悦,等.TPE输液器中苯乙烯和环己酮的相容性[J].塑料科技,2017,45(5):97-101.
15
刘慧,王健,李奇,等.高效液相色谱-三重四极杆串联质谱法测定一次性静脉留置针中双酚A残留量[J].中国药业,2024,33(7):79-83.
16
丁豪.超高效液相色谱-串联质谱法测定一次性使用输液器中双酚A的含量[J].药物分析杂志,2023,43(12):2121-2126.
17
李家春,孙兰,翁晓滨,等.聚氨酯输液器中7种异氰酸酯成分的提取与2种抗氧剂的溶出研究[J].塑料科技,2023,51(10):96-101.
18
王景春,严志宏,王昊.静脉留置针中MDI溶出测定及安全性评价[J].中国医疗器械信息,2018,24(21):36-38, 62.
19
代秀梅,于风平,贺敦伟,等.TPU输液器中MDI、抗氧剂1076和环己酮的溶出研究[J].药物分析杂志,2018,38(9):1587-1592.
20
韩海燕,蒲道俊,吴红洋,等.高效液相色谱法同时测定输液器中7种抗氧剂的迁移量[J].中国药业,2021,30(23):58-61.
21
于风平,赵锐,王彦厚.避光输液器中颜料橙64和DEHP的迁移溶出研究[J].药物分析杂志,2014,34(7):1327-1331.
22
于风平,代秀梅,赵锐,等.避光输液器中颜料棕25和UV-327的迁移溶出研究[J].药物分析杂志,2015,35(6):1058-1061.
23
葛蕾,赵昌军.一次性使用避光输液器中避光物质锌锡氧化物的迁移溶出研究[J].化学工程与装备,2022(7):15-17.
24
薛佳琪.环境友好型苯并三唑类紫外吸收剂的分子修饰及其机理研究[D].北京:华北电力大学,2023.
25
赖仲平,张焱.透明PVC药品包装材料透射率的研究[J].塑料助剂,2017(6):30-34.
26
LEE J K, KIM K B, LEE J D, et al. Risk assessment of drometrizole, a cosmetic ingredient used as an ultraviolet light absorber[J]. Toxicological Research, 2019, 35(2): 119-129.
27
CHAOCHANCHAIKUL K. Photodegradation profiles of PVC compound and wood/PVC composites under UV weathering[J]. eXPRESS Polymer Letters, 2013, 7(2): 146-160.
28
王磊,吴越,田冬.超声提取-高效液相色谱法测定化妆品中5种苯并三唑类紫外线吸收剂[J].日用化学工业:中英文,2023,53(1):109-114.
29
王磊,江洁.气相色谱法测定化妆品中4种苯并三唑类紫外线吸收剂的含量[J].理化检验-化学分册,2023,59(12):1437-1442.
30
李成发,陈麒宇,李英,等.Py-GC-MS快速测定食品接触材料中抗氧化剂和紫外吸收剂[J].塑料科技,2022,50(7):86-91.
31
BURNETT C L. Amended final report of the safety assessment of drometrizole as used in cosmetics[J].International Journal of Toxicology, 2008, 27(suppl 1): 63-75.

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