The material used for the pipeline distributor is polyamide66 (PA66), which is made by injection molding process and analyzed by molding flow by Moldflow software, and the injection molding process is affected by many factors. In this paper, the melt temperature, injection pressure, holding pressure and cooling time are taken as the research variables, and the warpage deformation of the parts is taken as the research objective to establish the response surface model, so as to reduce the warpage deformation of the parts by obtaining a set of better combinations of molding process parameters. The results show that when the melt temperature is 238 ℃, the injection pressure is 50 MPa, the holding pressure is 30 MPa and the cooling time is 110 s, the warpage deformation of the parts is 2.264 0 mm, which is reduced by 2.118 7 mm compared with before optimization, and the overall quality is significantly improved.