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The role of 3-hydroxy-3-methylglutaryl-coenzyme A reductase in liver diseases
ZENG Yangling, WANG Yunyong, GUAN Haimei, WANG Tianwen, XIE Baohua, LI Guobao, ZHANG Riyun, WANG Tingshuai, MAO Dewen
PDF(946 KB)
PDF(946 KB)
The role of 3-hydroxy-3-methylglutaryl-coenzyme A reductase in liver diseases
Cholesterol is an essential molecule for the biosynthesis of cell membranes and cell proliferation and differentiation,and the liver plays a central role in cholesterol metabolism and is responsible for the synthesis,uptake,secretion,and transport of cholesterol. The initial stages of cholesterol synthesis in the liver are particularly important,and abnormalities in such stages are closely associated with the progression of various liver diseases. Studies have shown that as a key rate-limiting enzyme in cholesterol biosynthesis,3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) has well-defined regulatory properties and has been confirmed as an important target for the regulation of various liver diseases. This article reviews the process of cholesterol metabolism,the degradation and regulatory mechanisms of HMGCR,and the application of inhibitors,as well as the role of HMGCR in liver diseases,in order to provide new insights for scientific research and the clinical prevention and treatment of liver diseases.
Liver Diseases / 3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase / Cholesterol
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曾阳玲、王运踊负责课题设计,资料分析,撰写论文,为共同第一作者;关海梅、王恬雯、谢宝华、李国宝、张日云参与收集数据及文献搜集与整理,修改论文;王挺帅指导撰写及修改文章;毛德文负责拟定写作思路,指导撰写并最后定稿。
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