PDF(1652 KB)
The regulatory role of tissue-resident memory T cells in chronic liver diseases and associated therapeutic targets
LIN Jin, ZENG Yu, TIAN Zhanfei, FAN Xiaoli
PDF(1652 KB)
PDF(1652 KB)
The regulatory role of tissue-resident memory T cells in chronic liver diseases and associated therapeutic targets
Tissue-resident memory T cells (TRM cells) are a subset of memory T cells that reside in tissues,exhibit tissue specificity,and do not recirculate. When potential hazards threaten the liver,such as pathogen invasion (bacteria,viruses,etc.) and excessive autoimmune responses,TRM cells are essential as the first line of immune defense,playing an important role in viral hepatitis,autoimmune liver disease,metabolic dysfunction-associated fatty liver disease,liver cirrhosis,and liver transplantation. Here,we present the immunophenotypes of TRM cells in the liver and their surface markers and transcriptional profiles,aiming to clarify the role of TRM cells in chronic liver diseases and explore their potential function as therapeutic targets in immunotherapy.
Tissue-resident Memory T Cells / Liver Diseases / Immunotherapy
| [1] |
|
| [2] |
|
| [3] |
|
| [4] |
王宁, 王一晗, 姜凤良, 等. 记忆性T细胞亚群及其分化调控研究进展[J]. 中国免疫学杂志, 2023, 39(6): 1326-1330, 1336. DOI: 10.3969/j.issn.1000-484X.2023.06.044.
|
| [5] |
|
| [6] |
|
| [7] |
|
| [8] |
|
| [9] |
|
| [10] |
RAY SJ,
|
| [11] |
|
| [12] |
|
| [13] |
|
| [14] |
|
| [15] |
|
| [16] |
|
| [17] |
|
| [18] |
|
| [19] |
|
| [20] |
|
| [21] |
|
| [22] |
|
| [23] |
|
| [24] |
|
| [25] |
|
| [26] |
|
| [27] |
|
| [28] |
|
| [29] |
|
| [30] |
|
| [31] |
|
| [32] |
|
| [33] |
|
| [34] |
|
| [35] |
|
| [36] |
|
| [37] |
|
| [38] |
|
| [39] |
|
| [40] |
|
| [41] |
|
| [42] |
|
| [43] |
|
| [44] |
|
| [45] |
|
| [46] |
|
| [47] |
|
林金、曾煜撰写和修改论文,二者对本文贡献相同;田展飞绘制图表;凡小丽指导撰写文章并最后定稿。
/
| 〈 |
|
〉 |