Role of ubiquitin-specific proteases in hepatocellular carcinoma

TANG Yi, WANG Guotai, JIANG Yuhan

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Journal of Clinical Hepatol ›› 2025, Vol. 41 ›› Issue (05) : 968-974. DOI: 10.12449/JCH250525
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Role of ubiquitin-specific proteases in hepatocellular carcinoma

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Abstract

Hepatocellular carcinoma （HCC） is a common primary malignant tumor. In recent years，the role of ubiquitin-specific proteases （USPs） in HCC has attracted widespread attention. USPs are a class of key deubiquitinating enzymes that affect a variety of biological processes by regulating the ubiquitination status of proteins. Studies have shown that USPs participate in the regulation of cell proliferation，apoptosis，migration，and invasion by deubiquitinating various tumor-related proteins. In addition，the abnormal expression of USPs is closely associated with the prognosis of HCC patients and may thus be used as potential biomarkers and therapeutic targets. This article reviews the research advances in USPs in HCC and explores their key roles in the development，progression，and metastasis of HCC. A deep understanding of the mechanism of action of USPs in HCC not only helps to reveal the pathogenesis of HCC，but also provides a scientific basis for developing new diagnostic tools and treatment strategies. Future research should further explore the regulatory effect of USPs in HCC，in order to provide more effective means for the clinical treatment of HCC.

Key words

Carcinoma，Hepatocellular / Ubiquitin-Specific Proteases / Enzyme Inhibitors

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TANG Yi , WANG Guotai , JIANG Yuhan. Role of ubiquitin-specific proteases in hepatocellular carcinoma. Journal of Clinical Hepatol. 2025, 41(05): 968-974 https://doi.org/10.12449/JCH250525

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唐怡负责资料分析，撰写论文；王国泰负责分析相关材料，并修改论文；蒋雨涵负责检索和收集相关文献。

Funding

Shaanxi Administration of Traditional Chinese Medicine(SZY-KJCYC-2025-JC-004)
Qinchuangyuan Traditional Chinese Medicine Industry Innovation Cluster Project(L2024-QCY-ZYYJJQ-Y09)
Young and Middle-aged Science and Technology Leaders in Xianyang City(L2022CXNLRC018)
Xianyang Science and Technology Bureau(2021ZDYF-SF-0037)

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