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Immunomodulatory effect of short-chain fatty acids in hepatic encephalopathy and its potential diagnostic value
CHEN Weiyu, MAO Dewen, WANG Han, DU Yang, FENG Wenqian, FU Lei, YAO Chun
PDF(1447 KB)
PDF(1447 KB)
Immunomodulatory effect of short-chain fatty acids in hepatic encephalopathy and its potential diagnostic value
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Hepatic encephalopathy (HE) is a common complication of severe liver disease in the end stage,and it is urgently needed to improve the rate of effective treatment and clarify the pathogenesis of HE. The liver is a crucial hub for immune regulation,and disruption of immune homeostasis is a key factor in the pathological mechanisms of HE. As the main metabolites of intestinal flora,short-chain fatty acids (SCFAs) play a vital role in the biological processes of both innate and adaptive immunity and can regulate the proliferation and differentiation of immune cells maintain the homeostasis of intestinal microenvironment and the integrity of barrier function. Studies have shown that SCFAs participate in bidirectional and dynamic interactions with the liver-gut-brain axis through immunomodulatory pathways,thereby playing an important role in the diagnosis,treatment,and prognostic evaluation of HE. Starting from the immunoregulatory effect of SCFAs,this article summarizes and analyzes the crosstalk relationship between SCFAs and the liver-gut-brain axis and the significance of SCFAs in the diagnosis and treatment of HE,in order to provide new ideas for optimizing clinical prevention and treatment strategies.
Hepatic Encephalopathy / Fatty Acids,Volatile / Immunomodulation / Gastrointestinal Microbiome
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姚春、陈玮钰负责研究选题并拟定写作思路;毛德文、王涵、付蕾负责设计论文框架;杜洋、冯雯倩负责收集和整理文献材料;陈玮钰负责文章撰写及修改。
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