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Role and regulatory mechanism of heme oxygenase in metabolic associated fatty liver disease
FEI Jinglan, LI Daozheng, WU Junchao, WANG Lei
PDF(823 KB)
PDF(823 KB)
Role and regulatory mechanism of heme oxygenase in metabolic associated fatty liver disease
This article systematically reviews the role and relationship of heme oxygenase (HO) in the pathogenesis of metabolic associated fatty liver disease (MAFLD) and discusses the biological function of HO,its expression in the liver,its association with lipid metabolism,and its regulatory role in inflammatory reaction and oxidative stress,in order to reveal the potential therapeutic targets and mechanism of HO in MAFLD and provide new perspectives and directions for future treatment strategies.
Metabolic Associated Fatty Liver Disease / Heme Oxygenase / Therapeutics
| [1] |
|
| [2] |
|
| [3] |
|
| [4] |
|
| [5] |
|
| [6] |
|
| [7] |
|
| [8] |
|
| [9] |
|
| [10] |
|
| [11] |
|
| [12] |
|
| [13] |
|
| [14] |
|
| [15] |
|
| [16] |
|
| [17] |
|
| [18] |
|
| [19] |
LYU YL,
吕永乐, 郑雯, 王签慧, 等. 抗代谢相关脂肪性肝病的天然活性物质研究进展[J]. 畜牧兽医学报, 2025, 56(1): 45-62.
|
| [20] |
|
| [21] |
易展, 贲定严, 徐寅, 等. 隔药饼灸激活Nrf2/ARE/HO-1信号通路修复阿司匹林诱导的胃黏膜损伤的机制研究[J]. 针刺研究, 2023, 48(8): 773-781. DOI: 10.13702/j.1000-0607.20220501.
|
| [22] |
王小雪, 樊官伟, 蒲翔, 等. 基于Nrf2/HO-1/NF-κB信号通路探讨马齿苋外用对变应性接触性皮炎小鼠的作用机制[J]. 中国实验方剂学杂志, 2025, 31(3): 115-123. DOI: 10.13422/j.cnki.syfjx.20241141.
|
| [23] |
|
| [24] |
郭君婷, 赵婷婷, 叶斯木·塔拉甫别克, 等. 基于Nrf2/HO-1信号通路调控的恰玛古多糖抗多柔比星心肌毒性的机制研究[J]. 药学学报, 2024, 59(4): 930-938. DOI: 10.16438/j.0513-4870.2023-1065.
|
| [25] |
方萌, 黄冬蕊, 张晋玮, 等. 丹参酮ⅡA调控PI3K/Akt与Nrf2/HO-1信号通路抑制氧化应激发挥抗肝细胞癌作用[J]. 中国中药杂志, 2024, 49(24): 6724-6734. DOI: 10.19540/j.cnki.cjcmm.20240711.401.
|
| [26] |
|
| [27] |
|
| [28] |
|
| [29] |
|
| [30] |
|
| [31] |
|
| [32] |
白文娅, 杨渊, 霍思颖, 等. 胆绿素治疗作用的研究进展[J]. 昆明医科大学学报, 2022, 43(6): 147-153. DOI: 10.12259/j.issn.2095-610X.S20220601.
|
| [33] |
|
| [34] |
|
| [35] |
|
| [36] |
吴璐璐, 郑泽泉, 赵敏, 等. 基于Nrf2/HO-1/HIF-1α通路探讨升降散对EAE鼠巨噬细胞的调控作用[J]. 时珍国医国药, 2024, 35(5): 1118-1122. DOI: 10.3969/j.issn.1008-0805.2024.05.21.
|
| [37] |
|
| [38] |
|
| [39] |
|
| [40] |
|
| [41] |
马成, 杨慧. 核因子E2相关因子2/血红素加氧酶-1(Nrf2/HO-1)信号通路在酒精性肝病中的作用[J]. 临床肝胆病杂志, 2023, 39(7): 1708-1713. DOI: 10.3969/j.issn.1001-5256.2023.07.028.
|
| [42] |
|
| [43] |
|
| [44] |
|
| [45] |
|
| [46] |
黄海锋, 庞晓妍, 戴卫波, 等. 柴胡疏肝颗粒调控Keap1-Nrf2/HO-1信号通路改善四氯化碳诱导的小鼠急性肝损伤[J]. 中国药学杂志, 2024, 59(8): 703-712. DOI: 10.11669/cpj.2024.08.006.
|
| [47] |
|
| [48] |
|
| [49] |
|
| [50] |
|
| [51] |
李国莺, 陈文静, 贾步云, 等. 地奥心血康上调Nrf2/HO-1信号通路改善小鼠非酒精性脂肪性肝炎的实验研究[J]. 中国中药杂志, 2022, 47(9): 2491-2499. DOI: 10.19540/j.cnki.cjcmm.20211115.401.
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