Role of triggering receptor expressed on myeloid cells 2 in acute and chronic liver diseases

Xinyue CUI, Quanhao SUN, Lihong ZHENG, Haiqiang WANG

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Journal of Clinical Hepatol ›› 2025, Vol. 41 ›› Issue (2) : 383-388. DOI: 10.12449/JCH250228
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Role of triggering receptor expressed on myeloid cells 2 in acute and chronic liver diseases

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Abstract

Triggering receptor expressed on myeloid cells 2 （TREM2） is expressed in resident non-parenchymal cells （NPCs） and is involved in various pathological processes including liver inflammation and immunoregulation. In recent years， TREM2 has attracted attention in the field of acute and chronic liver diseases， and more and more studies have shown that TREM2 is a potential target for the treatment of acute and chronic liver diseases； however， there is a lack of systematic summary for the mechanism of action of TREM2 in acute and chronic liver diseases. Therefore， this article reviews the latest research advances in the regulatory role of TREM2 in acute and chronic liver diseases， in order to provide new ideas for the clinical prevention and treatment of acute and chronic liver diseases.

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Triggering Receptor Expressed on Myeloid Cells 2 / Liver Diseases / Pathologic Processes

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Xinyue CUI , Quanhao SUN , Lihong ZHENG , et al. Role of triggering receptor expressed on myeloid cells 2 in acute and chronic liver diseases. Journal of Clinical Hepatol. 2025, 41(2): 383-388 https://doi.org/10.12449/JCH250228

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Funding

State Administration of Traditional Chinese Medicine, the Fifth Batch of National Chinese Medicine Clinical Excellence Training Program （the State Administration of Traditional Chinese Medicine Human Education Letter ［2022］ No.1）
Heilongjiang University of Traditional Chinese Medicine “Outstanding Young Backbone Teachers” Program(15041190018)

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