1	LI MM, JIA Y, WANG FX, et al. Mitochondrial dysfunction and chronic liver diseases[J]. Prog Physiol Sci, 2018, 49(2): 81-86. DOI: 10.3969/j.issn.0559-7765.2018.02.001 . 李蒙蒙, 贾岩, 王飞虾, 等. 线粒体功能障碍与慢性肝病[J]. 生理科学进展, 2018, 49(2): 81-86. DOI: 10.3969/j.issn.0559-7765.2018.02.001 . 本文引用 [1]

2

WANG H, LIU Y, YANG LY, et al. Research progress on antiviral activities and mechanism of alkaloids[J]. Chin Tradit Herb Drugs, 2022, 53(9): 2839-2850. DOI: 10.7501/j.issn.0253-2670.2022.09.028 . 王宏, 刘月, 杨梁钰, 等. 生物碱类化合物抗病毒活性及其机制研究进展[J]. 中草药, 2022, 53(9): 2839-2850. DOI: 10.7501/j.issn.0253-2670.2022.09.028 . 本文引用 [1]

3	KIM JA, KANG YS, LEE YS. A phospholipase C-dependent intracellular Ca2+ release pathway mediates the capsaicin-induced apoptosis in HepG2 human hepatoma cells[J]. Arch Pharm Res, 2005, 28(1): 73-80. DOI: 10.1007/BF02975139 . 本文引用 [1]

4

FU JH, YU FX, WANG Y, et al. Effect of capsaicin on apoptosis of hepatic stellate cells[J]. J Hepatopancreatobiliary Surg, 2012, 24(6): 466-469. DOI: 10.3969/j.issn.1007-1954.2012.06.008 . 符竣惠, 俞富祥, 汪洋, 等. 辣椒素对肝星状细胞增殖凋亡的影响[J]. 肝胆胰外科杂志, 2012, 24(6): 466-469. DOI: 10.3969/j.issn.1007-1954.2012.06.008 . 本文引用 [1]

5	HU JJ, LUO HH, JIANG Y, et al. Dietary capsaicin and antibiotics act synergistically to reduce non-alcoholic fatty liver disease induced by high fat diet in mice[J]. Oncotarget, 2017, 8(24): 38161-38175. DOI: 10.18632/oncotarget.16975 . 本文引用 [1]

6	KADOWAKI T, YAMAUCHI T, KUBOTA N, et al. Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome[J]. J Clin Invest, 2006, 116(7): 1784-1792. DOI: 10.1172/JCI29126 . 本文引用 [1]

7	HARDIE DG. AMPK: Sensing energy while talking to other signaling pathways[J]. Cell Metab, 2014, 20(6): 939-952. DOI: 10.1016/j.cmet.2014.09.013 . 本文引用 [2]

8	SHIN MK, YANG SM, HAN IS. Capsaicin suppresses liver fat accumulation in high-fat diet-induced NAFLD mice[J]. Anim Cells Syst (Seoul), 2020, 24(4): 214-219. DOI: 10.1080/19768354.2020.1810771 . 本文引用 [1]

9	KIM HJ, KO JW, CHA SB, et al. Evaluation of 13-week repeated oral dose toxicity of Areca catechu in F344/N rats[J]. Food Chem Toxicol, 2018, 114: 41-51. DOI: 10.1016/j.fct.2018.02.015 . 本文引用 [1]

10

GUO SK, ZHOU YL, LYU MS, et al. Protective effects of stachydrine on acute hepatic injury injured induced by CCl4 in mice[J]. J Taishan Med Coll, 2018, 39(12): 1357-1359. DOI: 10.3969/j.issn.1004-7115.2018.10.013 . 郭书凯, 周艳丽, 吕茂盛, 等. 水苏碱对四氯化碳致小鼠急性肝损伤的保护作用[J]. 泰山医学院学报, 2018, 39(12): 1357-1359. DOI: 10.3969/j.issn.1004-7115.2018.10.013 . 本文引用 [1]

11	BAO XM, LIU YM, HUANG JY, et al. Stachydrine hydrochloride inhibits hepatocellular carcinoma progression via LIF/AMPK axis[J]. Phytomedicine, 2022, 100: 154066. DOI: 10.1016/j.phymed.2022.154066 . 本文引用 [1]

12	YE Y, LI X, WANG ZH, et al. 3, 3'-Diindolylmethane induces gastric cancer cells death via STIM1 mediated store-operated calcium entry[J]. Int J Biol Sci, 2021, 17(5): 1217-1233. DOI: 10.7150/ijbs.56833 . 本文引用 [1]

13	MENZIES FM, MOREAU K, RUBINSZTEIN DC. Protein misfolding disorders and macroautophagy[J]. Curr Opin Cell Biol, 2011, 23(2): 190-197. DOI: 10.1016/j.ceb.2010.10.010 . 本文引用 [1]

14	BYUN SJ, KIM HS, JEON SM, et al. Supplementation of Areca catechu L. extract alters triglyceride absorption and cholesterol metabolism in rats[J]. Ann Nutr Metab, 2001, 45(6): 279-284. DOI: 10.1159/000046739 . 本文引用 [2]

15	ZHU LP, LI D, YANG XF. Gut metabolomics and 16S rRNA sequencing analysis of the effects of arecoline on non-alcoholic fatty liver disease in rats[J]. Front Pharmacol, 2023, 14: 1132026. DOI: 10.3389/fphar.2023.1132026 . 本文引用 [1]

16	BRON PA, KLEEREBEZEM M, BRUMMER RJ, et al. Can probiotics modulate human disease by impacting intestinal barrier function?[J]. Br J Nutr, 2017, 117(1): 93-107. DOI: 10.1017/S0007114516004037 . 本文引用 [2]

17	RAHEEM A, LIANG L, ZHANG GZ, et al. Modulatory effects of probiotics during pathogenic infections with emphasis on immune regulation[J]. Front Immunol, 2021, 12: 616713. DOI: 10.3389/fimmu.2021.616713 . 本文引用 [1]

18	ELAMIN EE, MASCLEE AA, DEKKER J, et al. Short-chain fatty acids activate AMP-activated protein kinase and ameliorate ethanol-induced intestinal barrier dysfunction in Caco-2 cell monolayers[J]. J Nutr, 2013, 143(12): 1872-1881. DOI: 10.3945/jn.113.179549 . 本文引用 [1]

19	CHANG XX, YAN HM, FEI J, et al. Berberine reduces methylation of the MTTP promoter and alleviates fatty liver induced by a high-fat diet in rats[J]. J Lipid Res, 2010, 51(9): 2504-2515. DOI: 10.1194/jlr.M001958 . 本文引用 [1]

20	LI C. Study on the mechanism of berberine regulating autophagy of hepatic stellate cells and its effect on liver fibrosis[D]. Chengdu: Chengdu Medical College, 2020. 李灿. 小檗碱调控肝星状细胞自噬及其对肝纤维化作用的机制研究[D]. 成都: 成都医学院, 2020. 本文引用 [1]

21	GUO T, WOO SL, GUO X, et al. Berberine ameliorates hepatic steatosis and suppresses liver and adipose tissue inflammation in mice with diet-induced obesity[J]. Sci Rep, 2016, 6: 22612. DOI: 10.1038/srep22612 . 本文引用 [1]

22

TAN YH, LI C, DENG FM, et al. Berberine relieves liver fibrosis in mice by inhibiting autophagy of hepatic stellate cells[J]. J Chengdu Med Coll, 2023, 18(1): 33-38. DOI: 10.3969/j.issn.1674-2257.2023.01.007 . 谭悦浩, 李灿, 邓峰美, 等. 小檗碱通过抑制肝星状细胞自噬改善小鼠肝纤维化[J]. 成都医学院学报, 2023, 18(1): 33-38. DOI: 10.3969/j.issn.1674-2257.2023.01.007 . 本文引用 [1]

23	RAFIEI H, OMIDIAN K, BANDY B. Comparison of dietary polyphenols for protection against molecular mechanisms underlying nonalcoholic fatty liver disease in a cell model of steatosis[J]. Mol Nutr Food Res, 2017, 61(9). DOI: 10.1002/mnfr.201600781 . 本文引用 [1]

24	ZHANG C, DENG JJ, LIU D, et al. Nuciferine inhibits proinflammatory cytokines via the PPARs in LPS-induced RAW264.7 cells[J]. Molecules, 2018, 23(10): 2723. DOI: 10.3390/molecules23102723 . 本文引用 [1]

25	GUO FC, YANG X, LI XX, et al. Nuciferine prevents hepatic steatosis and injury induced by a high-fat diet in hamsters[J]. PLoS One, 2013, 8(5): e63770. DOI: 10.1371/journal.pone.0063770 . 本文引用 [1]

26	YU H, LIN LB, ZHANG ZQ, et al. Targeting NF-κB pathway for the therapy of diseases: Mechanism and clinical study[J]. Signal Transduct Target Ther, 2020, 5(1): 209. DOI: 10.1038/s41392-020-00312-6 . 本文引用 [3]

27	FENG X, TAN WK, CHENG S, et al. Upregulation of microRNA-126 in hepatic stellate cells may affect pathogenesis of liver fibrosis through the NF-κB pathway[J]. DNA Cell Biol, 2015, 34(7): 470-480. DOI: 10.1089/dna.2014.2760 . 本文引用 [1]

28	ZHANG DD, ZHANG JG, WU X, et al. Nuciferine downregulates Per-Arnt-Sim kinase expression during its alleviation of lipogenesis and inflammation on oleic acid-induced hepatic steatosis in HepG2 cells[J]. Front Pharmacol, 2015, 6: 238. DOI: 10.3389/fphar.2015.00238 . 本文引用 [1]

29	YANG DM, LI L, QIAN SJ, et al. Evodiamine ameliorates liver fibrosis in rats via TGF-β1/Smad signaling pathway[J]. J Nat Med, 2018, 72(1): 145-154. DOI: 10.1007/s11418-017-1122-5 . 本文引用 [1]

30

KOBYLIAK N, ABENAVOLI L, MYKHALCHYSHYN G, et al. A multi-strain probiotic reduces the fatty liver index, cytokines and aminotransferase levels in NAFLD patients: Evidence from a randomized clinical trial[J]. J Gastrointestin Liver Dis, 2018, 27(1): 41-49. DOI: 10.15403/jgld.2014.1121.271.kby . 本文引用 [1]

31	KOBYLIAK N, ABENAVOLI L, FALALYEYEVA T, et al. Efficacy of probiotics and smectite in rats with non-alcoholic fatty liver disease[J]. Ann Hepatol, 2018, 17(1): 153-161. DOI: 10.5604/01.3001.0010.7547 . 本文引用 [1]

32	DAI YF, ZHU WY, ZHOU JX, et al. The combination of berberine and evodiamine ameliorates high-fat diet-induced non-alcoholic fatty liver disease associated with modulation of gut microbiota in rats[J]. Braz J Med Biol Res, 2022, 55: e12096. DOI: 10.1590/1414-431X2022e12096 . 本文引用 [1]

33	XIE N, CUI Y, YIN YN, et al. Effects of two Lactobacillus strains on lipid metabolism and intestinal microflora in rats fed a high-cholesterol diet[J]. BMC Complement Altern Med, 2011, 11: 53. DOI: 10.1186/1472-6882-11-53 . 本文引用 [1]

34	CHEN M, GUO WL, LI QY, et al. The protective mechanism of Lactobacillus plantarum FZU3013 against non-alcoholic fatty liver associated with hyperlipidemia in mice fed a high-fat diet[J]. Food Funct, 2020, 11(4): 3316-3331. DOI: 10.1039/c9fo03003d . 本文引用 [1]

35	NAGATA K, NISHIYAMA C. IL-10 in mast cell-mediated immune responses: Anti-inflammatory and proinflammatory roles[J]. Int J Mol Sci, 2021, 22(9): 4972. DOI: 10.3390/ijms22094972 . 本文引用 [1]

36

LIU YB, KE J, WENG SA, et al. The effects of henbane drugs on calcium accumulation of rat liver induced by carbon tetrachloride[J]. J Zhengzhou Univ Med Sci, 1988, 23(3): 227-229. DOI: 10.13705/j.issn.1671-6825.1988.03.009 . 刘元斌, 可君, 翁世艾, 等. 莨菪类药物对四氧化碳所致大鼠肝钙积累的作用[J]. 河南医科大学学报, 1988, 23(3): 227-229. DOI: 10.13705/j.issn.1671-6825.1988.03.009 . 本文引用 [1]

37

CUI RB, KAN BT, SUN XM, et al. Role of store-operated Ca2+ channels in primary hepatocytes under conditions of calcium overload and ethanol-induced injury[J]. Chin J Hepatol, 2013, 21(11): 860-864. DOI: 10.3760/cma.j.issn.1007-3418.2013.11.014 . 崔瑞冰, 阚宝甜, 孙晓萌, 等. 钙池操纵的钙离子通道在乙醇诱导的原代肝细胞钙超载及损伤中的作用[J]. 中华肝脏病杂志, 2013, 21(11): 860-864. DOI: 10.3760/cma.j.issn.1007-3418.2013.11.014 . 本文引用 [1]

38	XIE YH, CHEN DM, JIANG KJ, et al. Hair shaft miniaturization causes stem cell depletion through mechanosensory signals mediated by a Piezo1-calcium-TNF-α axis[J]. Cell Stem Cell, 2022, 29(1): 70-85. e6. DOI: 10.1016/j.stem.2021.09.009 . 本文引用 [1]

39	KHURANA S, JADEJA R, TWADDELL W, et al. Effects of modulating M3 muscarinic receptor activity on azoxymethane-induced liver injury in mice[J]. Biochem Pharmacol, 2013, 86(2): 329-338. DOI: 10.1016/j.bcp.2013.05.010 . 本文引用 [2]

40	CHOBERT MN, COUCHIE D, FOURCOT A, et al. Liver precursor cells increase hepatic fibrosis induced by chronic carbon tetrachloride intoxication in rats[J]. Lab Invest, 2012, 92(1): 135-150. DOI: 10.1038/labinvest.2011.143 . 本文引用 [1]

41	FANG CY, CAI XB, HAYASHI S, et al. Caffeine-stimulated muscle IL-6 mediates alleviation of non-alcoholic fatty liver disease[J]. Biochim Biophys Acta Mol Cell Biol Lipids, 2019, 1864(3): 271-280. DOI: 10.1016/j.bbalip.2018.12.003 . 本文引用 [1]

42	LI ZD, GENG MY, DOU SR, et al. Caffeine decreases hepcidin expression to alleviate aberrant iron metabolism under inflammation by regulating the IL-6/STAT3 pathway[J]. Life (Basel), 2022, 12(7): 1025. DOI: 10.3390/life12071025 . 本文引用 [1]

43	LENHART KF, CAPOZZOLI B, WARRICK GSD, et al. Diminished jak/STAT signaling causes early-onset aging defects in stem cell cytokinesis[J]. Curr Biol, 2019, 29(2): 256-267. e3. DOI: 10.1016/j.cub.2018.11.064 . 本文引用 [1]

44

CAO HK, GAO Y, HUANG SM, et al. Research on mechanism of effect of total flavonoids extracted from Polygonum perfoliatum L. on anti-hepatic fibrosis in rats[J]. Chin Pharmacol Bull, 2017, 33(9): 1303-1308. DOI: 10.3969/j.issn.1001-1978.2017.09.022 . 曹后康, 高雅, 黄思茂, 等. 杠板归总黄酮抗大鼠肝纤维化作用的机制研究[J]. 中国药理学通报, 2017, 33(9): 1303-1308. DOI: 10.3969/j.issn.1001-1978.2017.09.022 . 本文引用 [1]

45	GRESSNER OA, LAHME B, REHBEIN K, et al. Pharmacological application of caffeine inhibits TGF-beta-stimulated connective tissue growth factor expression in hepatocytes via PPARgamma and SMAD2/3-dependent pathways[J]. J Hepatol, 2008, 49(5): 758-767. DOI: 10.1016/j.jhep.2008.03.029 . 本文引用 [1]

46	SHIM SG, JUN DW, KIM EK, et al. Caffeine attenuates liver fibrosis via defective adhesion of hepatic stellate cells in cirrhotic model[J]. J Gastroenterol Hepatol, 2013, 28(12): 1877-1884. DOI: 10.1111/jgh.12317 . 本文引用 [1]

47	WU BN, KUO KK, CHEN YH, et al. Theophylline-based KMUP-1 improves steatohepatitis via MMP-9/IL-10 and lipolysis via HSL/p-HSL in obese mice[J]. Int J Mol Sci, 2016, 17(8): 1345. DOI: 10.3390/ijms17081345 . 本文引用 [1]

48	REIF S, SOMECH R, BRAZOVSKI E, et al. Matrix metalloproteinases 2 and 9 are markers of inflammation but not of the degree of fibrosis in chronic hepatitis C[J]. Digestion, 2005, 71(2): 124-130. DOI: 10.1159/000084626 . 本文引用 [1]

49	JUNG UJ, CHOI MS. Obesity and its metabolic complications: The role of adipokines and the relationship between obesity, inflammation, insulin resistance, dyslipidemia and nonalcoholic fatty liver disease[J]. Int J Mol Sci, 2014, 15(4): 6184-6223. DOI: 10.3390/ijms15046184 . 本文引用 [1]

50	GEBHARDT C. The historical role of species from the Solanaceae plant family in genetic research[J]. Theor Appl Genet, 2016, 129(12): 2281-2294. DOI: 10.1007/s00122-016-2804-1 . 本文引用 [1]

51

ZHOU XH, LU XL, YANG X, et al. Effect of ursolic acid on that expression and apoptosis of bcl-2 and Bax gene in laryngeal carcinoma Hep-2 cells[J]. Chin J Lab Diagn, 2021, 25(3): 434-437. DOI: 10.3969/j.issn.1007-4287.2021.03.040 . 周晓红, 卢晓丽, 杨雪, 等. 熊果酸对喉癌Hep-2细胞bcl-2、Bax基因表达和凋亡影响[J]. 中国实验诊断学, 2021, 25(3): 434-437. DOI: 10.3969/j.issn.1007-4287.2021.03.040 . 本文引用 [1]

52	YI YJ, JIA XH, WANG JY, et al. Solanine induced apoptosis and increased chemosensitivity to Adriamycin in T-cell acute lymphoblastic leukemia cells[J]. Oncol Lett, 2018, 15(5): 7383-7388. DOI: 10.3892/ol.2018.8229 . 本文引用 [1]

53	GAO SY, WANG QJ, JI YB. Effect of solanine on the membrane potential of mitochondria in HepG2 cells and[Ca2+]i in the cells[J]. World J Gastroenterol, 2006, 12(21): 3359-3367. DOI: 10.3748/wjg.v12.i21.3359 . 本文引用 [1]

54	LUO S, TIAN GJ, YU FX, et al. A narrative review of the antitumor studies of solanine[J]. Transl Cancer Res, 2021, 10(3): 1578-1582. DOI: 10.21037/tcr-20-3094 . 本文引用 [1]

55	HASANAIN M, BHATTACHARJEE A, PANDEY P, et al. α-Solanine induces ROS-mediated autophagy through activation of endoplasmic reticulum stress and inhibition of Akt/mTOR pathway[J]. Cell Death Dis, 2015, 6(8): e1860. DOI: 10.1038/cddis.2015.219 . 本文引用 [1]

56	HIGASHI T, FRIEDMAN SL, HOSHIDA Y. Hepatic stellate cells as key target in liver fibrosis[J]. Adv Drug Deliv Rev, 2017, 121: 27-42. DOI: 10.1016/j.addr.2017.05.007 . 本文引用 [1]

57	WEN ZD, HUANG CH, XU YY, et al. α-Solanine inhibits vascular endothelial growth factor expression by down-regulating the ERK1/2-HIF-1α and STAT3 signaling pathways[J]. Eur J Pharmacol, 2016, 771: 93-98. DOI: 10.1016/j.ejphar.2015.12.020 . 本文引用 [1]

58	YIN TP, CAI L, HE JM, et al. Three new diterpenoid alkaloids from the roots of Aconitum duclouxii [J]. J Asian Nat Prod Res, 2014, 16(4): 345-350. DOI: 10.1080/10286020.2014.881802 . 本文引用 [1]

59	ZHANG XM, MA JY, SONG N, et al. Lappaconitine sulfate inhibits proliferation and induces apoptosis in human hepatocellular carcinoma HepG2 cells through the reactive oxygen species-dependent mitochondrial pathway[J]. Pharmacology, 2020, 105(11-12): 705-714. DOI: 10.1159/000506081 . 本文引用 [2]

60	GINTER E, SIMKO V, PANAKOVA V. Antioxidants in health and disease[J]. Bratisl Lek Listy, 2014, 115(10): 603-606. DOI: 10.4149/bll_2014_116 . 本文引用 [1]

61	BORCSA B, FODOR L, CSUPOR D, et al. Diterpene alkaloids from the roots of Aconitum moldavicum and assessment of Nav 1.2 sodium channel activity of Aconitum alkaloids[J]. Planta Med, 2014, 80(2-3): 231-236. DOI: 10.1055/s-0033-1360278 . 本文引用 [1]

62	YANG HQ, WANG H, LIU YB, et al. The PI3K/Akt/mTOR signaling pathway plays a role in regulating aconitine-induced autophagy in mouse liver[J]. Res Vet Sci, 2019, 124: 317-320. DOI: 10.1016/j.rvsc.2019.04.016 . 本文引用 [1]