Molecular mechanisms of the interaction between hepatitis B virus infection and mitochondrial homeostasis

Xingtong LI, Taicheng ZHOU

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Journal of Clinical Hepatol ›› 2025, Vol. 41 ›› Issue (2) : 343-348. DOI: 10.12449/JCH250222
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Molecular mechanisms of the interaction between hepatitis B virus infection and mitochondrial homeostasis

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Abstract

Hepatitis B virus （HBV） infection can cause acute or chronic infection， while untreated patients can develop into liver cirrhosis or liver cancer， thereby leading to death. As one of the most important organelles of cells， the maintenance of the normal morphology and function of mitochondria is the basis for ensuring various physiological activities in cells， and physiological activities， such as mitochondrial dynamics， mitophagy， injury， and oxidative phosphorylation， can affect the maintenance of mitochondrial homeostasis. HBV infection can affect mitochondrial homeostasis. This article summarizes the research advances in mitochondrial homeostasis and HBV infection from the four aspects of mitochondrial dynamics， mitophagy， mitochondrial oxidative phosphorylation， and mitochondrial injury and discusses the association between the maintenance of mitochondrial homeostasis and HBV infection， in order to provide a theoretical basis for understanding the molecular mechanism of HBV infection and identifying the potential therapeutic targets for HBV.

Key words

Hepatitis B Virus / Mitochondria / Mitochondrial Dynamics / Mitophagy / Oxidative Phosphorylation

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Xingtong LI , Taicheng ZHOU. Molecular mechanisms of the interaction between hepatitis B virus infection and mitochondrial homeostasis. Journal of Clinical Hepatol. 2025, 41(2): 343-348 https://doi.org/10.12449/JCH250222

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李兴统负责文稿的撰写；周太成负责文稿的审校及修改。

Funding

Yunnan Provincial Department of Science and Technology-Kunming Medical University Basic Research Joint Special Project(202101AY070001-283)
Yunnan Province High-level Scientific and Technological Talents and Innovative Teams Selection Special Programme(202105AC160048)

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