Molecular mechanisms of traditional Chinese medicine in reversing liver fibrosis

Xiaoling GUO, Zhansheng JIA, Jing ZHANG

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Journal of Clinical Hepatol ›› 2025, Vol. 41 ›› Issue (1) : 170-175. DOI: 10.12449/JCH250126
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Molecular mechanisms of traditional Chinese medicine in reversing liver fibrosis

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Abstract

Liver fibrosis is the intermediate stage in the progression of many chronic liver diseases to liver cirrhosis， and although there is still a lack of widely accepted and effective chemical or biological agents for reversing liver fibrosis， significant progress has been made in the treatment of liver fibrosis with traditional Chinese medicine. This article elaborates on the molecular mechanisms of different herbal extracts， a single Chinese herb， and Chinese patent drugs in reversing liver fibrosis， such as inhibiting liver inflammation， exerting an effect on lipid peroxidation damage， inhibiting the activation and proliferation of hepatic stellate cells， regulating the synthesis and secretion of pro-fibrogenic factors， and regulating the synthesis and degradation of extracellular matrix， in order to provide more precise options for the treatment of liver fibrosis in the future.

Key words

Hepatic Fibrosis / Anti-Hepato Fibrosis Agents （TCD） / Molecular Mechanisms of Pharmacological Action

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Xiaoling GUO , Zhansheng JIA , Jing ZHANG. Molecular mechanisms of traditional Chinese medicine in reversing liver fibrosis. Journal of Clinical Hepatol. 2025, 41(1): 170-175 https://doi.org/10.12449/JCH250126

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National Natural Science Foundation of China Young Scientist Fund(8230081752)

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