Effect of hepatitis B virus integration on functional cure

Xiaoqi YU, Xinxin ZHANG

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Journal of Clinical Hepatol ›› 2025, Vol. 41 ›› Issue (1) : 24-29. DOI: 10.12449/JCH250104
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Effect of hepatitis B virus integration on functional cure

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Abstract

Functional cure is currently recommended by guidelines as the ideal treatment goal for the prevention and treatment of chronic hepatitis B （CHB） in China and globally， and it is defined as sustained and undetectable serum HBsAg and HBV DNA， HBeAg clearance， and presence or absence of HBsAg seroconversion， accompanied by resolution of liver inflammation， histopathological improvements， and a significant reduction in the incidence rate of end-stage liver disease. HBV can integrate into the host genome and contribute to the continuous production of HBsAg， which can occur in the early stage of chronic HBV infection. In addition to the covalently closed circular DNA that is hard to be eliminated in liver tissue， HBsAg derived from HBV integration independent of viral replication may be the most important factor for the difficulty in achieving functional cure after antiviral therapy in patients with hepatitis B. This article reviews the research advances in HBV integration in recent years and discusses its impact on functional cure.

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Hepatitis B Virus / Genes / Functional Cure / Antiviral Therapy

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Xiaoqi YU , Xinxin ZHANG. Effect of hepatitis B virus integration on functional cure. Journal of Clinical Hepatol. 2025, 41(1): 24-29 https://doi.org/10.12449/JCH250104

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Funding

National Natural Science Foundation of China Young Scientist Fund(82402601)
General Project of Natural Science Foundation of Shanghai(24ZR1448400)

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