PDF(972 KB)
How far is the functional cure of chronic hepatitis B from complete cure?
Na GAO, Zhiliang GAO
PDF(972 KB)
PDF(972 KB)
How far is the functional cure of chronic hepatitis B from complete cure?
Functional cure is currently the ideal treatment endpoint for chronic hepatitis B (CHB) in China and globally. HBsAg seroclearance and HBV DNA that cannot be detected in peripheral blood for more than 24 weeks marks the regression of hepatitis B virus (HBV) infection. However, there is still a lack of systematic description of the characteristics of intrahepatic HBV markers after HBsAg seroclearance. This article elaborates on the issues including the latest definition of functional cure, the characteristics of intrahepatic virological markers after HBsAg seroclearance, the significance of ultrasensitive serum HBsAg detection, and antiviral therapy for CHB patients with a low level of HBsAg, so as to improve the understanding of functional cure among clinicians.
Hepatitis B, Chronic / Functional Cure / Hepatitis B Surface Antigens / DNA, Viral
| 1 |
WHO. World health statistics 2022: monitoring health for the SDGs, sustainable development goals[M]. Geneva: World Health Organization, 2022.
|
| 2 |
|
| 3 |
Chinese Society of Infectious Disease, Chinese Society of Hepatology, Chinese Medical Association. The expert consensus on functional cure of chronic hepatitis B[J]. J Clin Hepatol, 2019, 35(8): 1693-1701. DOI: 10.3969/j.issn.1001-5256.2019.08.008 .
中华医学会感染病学分会, 中华医学会肝病学分会. 慢性乙型肝炎临床治愈(功能性治愈)专家共识[J]. 临床肝胆病杂志, 2019, 35(8): 1693-1701. DOI: 10.3969/j.issn.1001-5256.2019.08.008 .
|
| 4 |
|
| 5 |
|
| 6 |
|
| 7 |
LOK AS,
|
| 8 |
|
| 9 |
|
| 10 |
YIP TCF,
|
| 11 |
|
| 12 |
|
| 13 |
|
| 14 |
|
| 15 |
|
| 16 |
|
| 17 |
|
| 18 |
|
| 19 |
|
| 20 |
|
| 21 |
|
| 22 |
|
| 23 |
|
| 24 |
|
| 25 |
|
| 26 |
|
| 27 |
|
| 28 |
|
| 29 |
|
| 30 |
|
| 31 |
MAK LY,
|
| 32 |
|
| 33 |
|
| 34 |
|
| 35 |
|
| 36 |
|
| 37 |
|
| 38 |
|
| 39 |
|
| 40 |
|
| 41 |
|
| 42 |
|
| 43 |
卢建华, 杨莉, 赵召霞, 等. 高敏与普通荧光定量PCR技术在慢乙肝患者抗病毒疗效监测中的对比研究[J]. 分子诊断与治疗杂志, 2019, 11(5): 361-364. DOI: 10.3969/j.issn.1674-6929.2019.05.005 .
|
| 44 |
封波, 郑佳睿, 王资隆. 高灵敏乙型肝炎病毒表面抗原和DNA检测的临床应用价值[J]. 中华检验医学杂志, 2023, 46(1): 7-11. DOI: 10.3760/cma.j.cn114452-20220817-00475 .
|
| 45 |
|
| 46 |
|
| 47 |
|
| 48 |
|
| 49 |
|
| 50 |
|
| 51 |
|
| 52 |
|
| 53 |
|
| 54 |
|
| 55 |
|
| 56 |
|
| 57 |
鲁凤民, 封波, 郑素军, 等. 核苷(酸)类似物经治的慢性乙型肝炎患者低病毒血症的研究现状[J]. 临床肝胆病杂志, 2021, 37(6): 1268-1274. DOI: 10.3969/j.issn.1001-5256.2021.06.007 .
|
| 58 |
|
| 59 |
|
| 60 |
|
| 61 |
|
| 62 |
|
| 63 |
|
| 64 |
|
| 65 |
|
| 66 |
|
| 67 |
|
| 68 |
|
| 69 |
|
| 70 |
|
| 71 |
|
| 72 |
|
| 73 |
LIM SG,
|
| 74 |
|
| 75 |
|
| 76 |
|
| 77 |
|
| 78 |
|
| 79 |
|
高娜负责文章撰写;高志良负责拟定写作思路,指导文章撰写,修改论文并最后定稿。
/
| 〈 |
|
〉 |