组织驻留记忆T细胞在慢性肝病中的调控机制与治疗靶点

林金; 曾煜; 田展飞; 凡小丽

doi:10.12449/JCH250526

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临床肝胆病杂志 ›› 2025, Vol. 41 ›› Issue (05) : 975-982. DOI: 10.12449/JCH250526

综述

组织驻留记忆T细胞在慢性肝病中的调控机制与治疗靶点

作者信息 +

The regulatory role of tissue-resident memory T cells in chronic liver diseases and associated therapeutic targets

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History +

摘要

组织驻留记忆T细胞（T_RM细胞）是一类存在于组织中，具有组织特异性且不参与循环的记忆T细胞亚群。当潜在的危险攻击肝脏，如病原体（细菌或病毒等）侵袭或自身免疫反应过强时，T_RM细胞作为第一道免疫防线，在病毒性肝炎、自身免疫性肝病、代谢相关脂肪性肝病、肝硬化和肝移植中都发挥着重要作用。本文阐述了肝脏T_RM细胞的免疫表型，包括其表面标志物和转录谱，旨在进一步研究肝脏T_RM细胞在慢性肝病中的作用，并探索其作为免疫治疗靶点的潜在功能。

Abstract

Tissue-resident memory T cells （T_RM cells） are a subset of memory T cells that reside in tissues，exhibit tissue specificity，and do not recirculate. When potential hazards threaten the liver，such as pathogen invasion （bacteria，viruses，etc.） and excessive autoimmune responses，T_RM cells are essential as the first line of immune defense，playing an important role in viral hepatitis，autoimmune liver disease，metabolic dysfunction-associated fatty liver disease，liver cirrhosis，and liver transplantation. Here，we present the immunophenotypes of T_RM cells in the liver and their surface markers and transcriptional profiles，aiming to clarify the role of T_RM cells in chronic liver diseases and explore their potential function as therapeutic targets in immunotherapy.

导出引用

林金 , 曾煜 , 田展飞 , 等. 组织驻留记忆T细胞在慢性肝病中的调控机制与治疗靶点. 临床肝胆病杂志. 2025, 41(05): 975-982 https://doi.org/10.12449/JCH250526

LIN Jin, ZENG Yu, TIAN Zhanfei, et al. The regulatory role of tissue-resident memory T cells in chronic liver diseases and associated therapeutic targets[J]. Journal of Clinical Hepatol. 2025, 41(05): 975-982 https://doi.org/10.12449/JCH250526

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作者贡献声明

林金、曾煜撰写和修改论文，二者对本文贡献相同；田展飞绘制图表；凡小丽指导撰写文章并最后定稿。

基金

国家自然科学基金(82100552)

四川大学-达州校市合作专项资金(2022CDDZ-18)

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Received	Accepted	Published
2024-09-18	2024-10-22	2025-05-25
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