肿瘤出芽是一种存在于多种实体癌中的特殊病理形态学表现。近年来，肿瘤出芽被认为是肿瘤侵袭和转移的重要生物学特征，成为研究肿瘤进展的新焦点。尽管已有研究探讨了肿瘤出芽在多种肿瘤中的作用，但其在肝细胞癌领域的相关研究仍然相对较少。本综述旨在系统地回顾肝细胞癌中肿瘤出芽的研究进展，重点分析肿瘤出芽机制、出芽与肿瘤进展的关系及其在预后评估中的潜在应用，力求为肝细胞癌的早期诊断及治疗提供新的思路和策略。

Tumor budding is a distinct pathomorphological feature observed in various types of solid tumor. In recent years，tumor budding has been recognized as an important biological feature associated with tumor invasion and metastasis，and it has become a new focus in the research on tumor progression. Although studies have explored the role of tumor budding in different types of tumor，there are studies in the field of hepatocellular carcinoma （HCC）. This article systematically reviews the research advances in tumor budding in HCC，with a focus on the mechanism of tumor budding，the association between tumor budding and tumor progression，and the potential application of tumor budding in prognostic assessment，in order to provide new insights and strategies for the early diagnosis and treatment of HCC.