风湿性疾病肝脏受累的诊断与治疗

阙子媛, 孟繁星, 刘春桐, 刘燕鹰, 齐海宇

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临床肝胆病杂志 ›› 2025, Vol. 41 ›› Issue (05) : 806-811. DOI: 10.12449/JCH250502
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风湿性疾病肝脏受累的诊断与治疗

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Diagnosis and treatment of liver involvement secondary to rheumatic diseases

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摘要

风湿性疾病是一类慢性、炎症性自身免疫性疾病，可累及多个器官及系统。临床中风湿病患者在病程中大多表现为无症状肝功能异常，病因与风湿性疾病本身、药物、代谢、病毒或合并其他慢性肝病有关。免疫介导的炎症反应在风湿病肝脏受累（包括肝细胞损伤、肝内血管病变、肝纤维化）中发挥重要作用。本文对风湿性疾病相关肝脏受累的临床特征及诊治要点进行探讨，以提高相关专科医生对该病的认识。

Abstract

Rheumatic diseases are chronic inflammatory autoimmune diseases that can affect multiple organs and systems. In clinical practice，most patients with rheumatic diseases present with asymptomatic liver function abnormalities during the course of the disease，and the etiology of such diseases may be associated with the rheumatic disease itself，medications，metabolism，viruses，or the presence of other chronic liver diseases. Immune-mediated inflammatory responses play a significant role in liver involvement （including hepatocyte injury，intrahepatic vascular lesions，and hepatic fibrosis） in rheumatic diseases. This article discusses the clinical features and management of liver involvement secondary to rheumatic diseases，in order to enhance the understanding of this condition among specialists in related fields.

关键词

风湿性疾病 / 肝脏受累 / 诊断 / 治疗学

Key words

Rheumatic Diseases / Liver Involvement / Diagnosis / Therapeutics

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阙子媛 , 孟繁星 , 刘春桐 , 等. 风湿性疾病肝脏受累的诊断与治疗. 临床肝胆病杂志. 2025, 41(05): 806-811 https://doi.org/10.12449/JCH250502
QUE Ziyuan, MENG Fanxing, LIU Chuntong, et al. Diagnosis and treatment of liver involvement secondary to rheumatic diseases[J]. Journal of Clinical Hepatol. 2025, 41(05): 806-811 https://doi.org/10.12449/JCH250502

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作者贡献声明

阙子媛负责资料分析，撰写论文；孟繁星、刘春桐参与查阅文献，修改论文；齐海宇、刘燕鹰负责课题设计，拟定写作思路，指导撰写文章并最后定稿。

基金

北京自然科学基金面上项目(7222039)
北京自然科学基金面上项目(7232029)

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