肝性脑病中医/壮医“浊毒致病”理论及防治策略的构建与实践

吴智鹏, 张钰琴, 姚春, 王明刚, 王娜, 彭梦如, 磨宁芳, 郑娅晴, 张荣臻, 毛德文

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中国高校科技期刊信息汇聚平台
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临床肝胆病杂志 ›› 2025, Vol. 41 ›› Issue (2) : 370-374. DOI: 10.12449/JCH250226
综述

肝性脑病中医/壮医“浊毒致病”理论及防治策略的构建与实践

作者信息 +

Construction and practice of the theory of “turbid toxin pathogenesis” and related prevention and treatment strategies for hepatic encephalopathy in traditional Chinese medicine/Zhuang medicine

Author information +
History +

摘要

肝性脑病为肝病领域的疑难危重疾病，进展迅速、治疗手段有限、发病机制亟待突破。选择合适的防治策略，对于延缓疾病进展、降低发病率和病死率起到重要作用。本文就中医/壮医肝性脑病“浊毒致病”理论及防治策略进行述评，提出肝性脑病中医/壮医“浊毒致病”新学说，解析“浊”“毒”及“浊毒致病”理论的科学内涵，构建肝性脑病“四步曲”防治策略，并以此为基础延伸出以“四方两技法”为代表的肝性脑病临床防治新方案，继而阐明核心方药与技法防治肝性脑病的效应机制与生物学基础，以期为肝性脑病的防治提供参考。

Abstract

Hepatic encephalopathy is a difficult and critical disease with rapid progression and limited treatment methods in the field of liver disease， and it is urgently needed to make breakthroughs in its pathogenesis. Selection of appropriate prevention and treatment strategies is of great importance in delaying disease progression and reducing the incidence and mortality rates. This article reviews the theory of “turbid toxin pathogenesis” and related prevention and treatment strategies for hepatic encephalopathy in traditional Chinese medicine/Zhuang medicine， proposes a new theory of “turbid toxin pathogenesis”， analyzes the scientific connotations of “turbid”， “toxin”， and the theory of “turbid toxin pathogenesis”， and constructs the “four-step” prevention and treatment strategies for hepatic encephalopathy， thereby establishing the new clinical prevention and treatment regimen for hepatic encephalopathy represented by “four prescriptions and two techniques” and clarifying the effect mechanism and biological basis of core prescriptions and techniques in the prevention and treatment of hepatic encephalopathy， in order to provide a reference for the prevention and treatment of hepatic encephalopathy.

关键词

肝性脑病 / 浊毒致病 / 治疗学

Key words

Hepatic Encephalopathy / Turbid Toxin Pathogenic / Therapeutics

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吴智鹏 , 张钰琴 , 姚春 , 等. 肝性脑病中医/壮医“浊毒致病”理论及防治策略的构建与实践. 临床肝胆病杂志. 2025, 41(2): 370-374 https://doi.org/10.12449/JCH250226
Zhipeng WU, Yuqin ZHANG, Chun YAO, et al. Construction and practice of the theory of “turbid toxin pathogenesis” and related prevention and treatment strategies for hepatic encephalopathy in traditional Chinese medicine/Zhuang medicine[J]. Journal of Clinical Hepatol. 2025, 41(2): 370-374 https://doi.org/10.12449/JCH250226

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作者贡献声明

吴智鹏、张钰琴负责撰写论文；彭梦如、磨宁芳、郑娅晴参与修改论文；姚春、王明刚、王娜负责拟定写作思路；毛德文、张荣臻指导撰写文章并最后定稿。

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