PDF(972 KB)
慢性乙型肝炎功能性治愈离完全治愈还有多远?
高娜, 高志良
PDF(972 KB)
PDF(972 KB)
慢性乙型肝炎功能性治愈离完全治愈还有多远?
How far is the functional cure of chronic hepatitis B from complete cure?
功能性治愈是目前国内外慢性乙型肝炎的理想抗病毒治疗终点,其外周血HBsAg清除及HBV DNA检测不到并维持24周以上,标志着HBV感染的消退。然而,针对HBsAg清除后的肝内HBV标志物特点尚未有系统性描述。本文针对慢性乙型肝炎功能性治愈的最新定义、血清HBsAg清除后的肝内病毒学标志物特征、血清HBsAg高敏检测意义及低水平HBsAg是否需要治疗等问题等进行阐述,以期提高临床医生对慢性乙型肝炎功能性治愈的认识。
Functional cure is currently the ideal treatment endpoint for chronic hepatitis B (CHB) in China and globally. HBsAg seroclearance and HBV DNA that cannot be detected in peripheral blood for more than 24 weeks marks the regression of hepatitis B virus (HBV) infection. However, there is still a lack of systematic description of the characteristics of intrahepatic HBV markers after HBsAg seroclearance. This article elaborates on the issues including the latest definition of functional cure, the characteristics of intrahepatic virological markers after HBsAg seroclearance, the significance of ultrasensitive serum HBsAg detection, and antiviral therapy for CHB patients with a low level of HBsAg, so as to improve the understanding of functional cure among clinicians.
乙型肝炎, 慢性 / 功能性治愈 / 乙型肝炎表面抗原 / DNA, 病毒
Hepatitis B, Chronic / Functional Cure / Hepatitis B Surface Antigens / DNA, Viral
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高娜负责文章撰写;高志良负责拟定写作思路,指导文章撰写,修改论文并最后定稿。
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