PDF(769 KB)
Research progress of mitophagy in the onset and development of periodontal disease
Abulaiti Guliqihere,Qin Xu,Zhu Guangxun
PDF(769 KB)
PDF(769 KB)
Research progress of mitophagy in the onset and development of periodontal disease
),Qin Xu,Zhu Guangxun()Periodontal disease is a chronic inflammatory disease leading to the destruction of periodontal tissues caused by dental plaque biofilm. It ischaracterized by gingival inflammation and progressive destruction of alveolar bone. Mitophagy is a major mechanism that regulates cellular homeostasis by selectively eliminating dysfunctional or damaged mitochondria through autophagy, which plays a critical role in the mitochondrial quality and quantity control. Recent studies indicated that mitophagy participates in the development of periodontal diseases by inhibiting periodontal inflammation, decreasing cell apoptosis, and promoting osteogenic differentiation in periodontal ligament stem cells. Moreover, it provides a promising therapeutic strategy for the treatment of periodontal disease. Therefore, this review summarizes the progress of research on the definition of mitophagy, its molecular mechanism, and the role of mitophagy in the onset and development of periodontal disease.
periodontal disease / mitophagy / inflammation / cell apoptosis / osteogenic differentiation
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