PDF(804 KB)
Research progress on the antibacterial mechanism of oral local anesthetics
Tan Yongzhen,Liang Xinhua
PDF(804 KB)
PDF(804 KB)
Research progress on the antibacterial mechanism of oral local anesthetics
),Liang Xinhua()Local anesthetic is a kind of drug commonly used in oral outpatient operations. It has anesthetic and analgesic effects, and it can alleviate the pain of patients and facilitate treatment. Many studies have shown that local anesthetics have antibacterial effects, and they can effectively inhibit the growth of various bacteria and fungi. In this paper, the antibacterial effects of local anesthetics commonly used in dentistry (lidocaine, bupivacaine, ropivacaine, articaine, etc.) were summarized, and their molecular mechanisms were discussed (including changes in cell wall and membrane permeability, direct damage to cell membranes, inhibition of protein and genetic material synthesis, inhibition of cell respiration, etc.). The interaction with other drugs (antibiotics, epinephrine, opioids, etc.) also were studied. This work will be helpful in the selection of local anesthetics in oral clinics and the prevention and control of infection.
local anesthetics / antibacterial / dentistry
R78
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