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Regulation of inflammatory bowel disease via the gut microbiota-mediated brain-gut axis pathway
YANG Can-jiao, WANG Mei, YANG Heng-li, ZHANG Jian-ying, QIN Dong-dong, HE Hong-ping, LI Yan-ping
PDF(838 KB)
PDF(838 KB)
Regulation of inflammatory bowel disease via the gut microbiota-mediated brain-gut axis pathway
Inflammatory bowel disease (IBD) is a prevalent functional gastrointestinal disorder in clinical settings. Current research on the pathogenesis of IBD mainly focuses on genetic susceptibility, psychosocial stress, visceral hypersensitivity, dysregulation of the brain - gut axis, dysbiosis of the gut microbiota, and abnormalities in the intestinal mucosal immune system. However, these pathogenic mechanisms are not discrete entities. As research advances, the aberrant regulation of the brain - gut axis is increasingly recognized. This article delves into the correlation between gut microbiota dysbiosis and dysregulation of the brain - gut axis in IBD, offering compelling evidence for the interconnected pathogenic mechanisms involving the brain - gut axis and gut microbiota dysfunction in IBD.
inflammatory bowel disease / gut microbiota / brain - gut axis
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