B、N和F共掺杂的新型碳点对硝唑类抗生素的检测（英文）

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Journal of Shanxi University(Natural Science Edition) ›› 2025, Vol. 48 ›› Issue (03) : 578-588. DOI: 10.13451/j.sxu.ns.2024167

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Abstract

Blue fluorescent carbon dots (BNF-CDs) co-doped with boron, nitrogen and fluorine were prepared by a one-step solvothermal method using sodium fluoroborate, citric acid, ethylamine and acetonitrile as precursors. Herein, the structure, morphology and optical properties of BNF-CDs were characterized by transmission electron microscopy, Fourier transform infrared spectrometer, X-ray photoelectron spectroscopy, UV-Vis absorption and fluorescence spectroscopy, respectively. The results illustrated that the BNF-CDs have stable and excellent optical properties with a high fluorescence quantum yield of 65.9%. Based on the internal filtration effect between BNF-CDs and nitroimidazole antibiotics, the fluorescence of BNF-CDs can be effectively quenched. This phenomenon provides a novel fluorescence method for the determination of metronidazole (MTR), ornidazole (ORN) and tinidazole (TIN), and the corresponding detection curves for these nitroimidazole antibiotics were established, with linear ranges of 6-250 μmol/L for MTR, 3.6-189 μmol/L for ORN and 3.6-295 μmol/L for TIN. The detection limits were found to be 16 nmol/L, 35 nmol/L and 71 nmol/L, respectively. In addition, satisfactory recovery rates (rangihg from 96.4% to 105.8%) have been achieved for determination of MTR, ORN and TIN in actual samples,which indicates its potential application in the future.

Key words

nitroimidazole antibiotics / carbon dots / internal filtration effect / multifunctional detection

CLC number

O657.3

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