Golgi protein 73 (GP73) is a glycosylated transmembrane protein located in the cis-Golgi mem-brane, which plays an important role in the development of tumors and is a potential target for tumor therapy. Current studies have shown that GP73 can be used as a serological marker to assist the diagnosis of hepatocellular carcinoma (HCC). With the further study of GP73, microRNAs (miRNAs) related to GP73 have been gradually explored and found to be closely associated with the occurrence and development of various tumors. miR-212 and miR-27a can inhibit the invasion and metastasis of HCC, and GP73, miR-27b and miR-493-5p can be used as biomarkers for prognosis of HCC patients. Therefore, GP73-related miRNAs are promising targets for the diagnosis and treatment of liver cancer. Herein, the roles and mechanisms of GP73 and its related miRNAs in the development of HCC are summarized, hoping to provide ideas for the tumor pathogenesis, diagnosis and treatment.