Non-coding RNAs (ncRNAs), which are abundant in organisms, have been of special concern in recent years. Most ncRNAs do not encode proteins, but they play a significant role in participating complex signaling cascades in various diseases by regulating gene expression and protein functions. Pancreatic cancer is known as the king of cancer because its early symptoms are not obvious, diagnosis often occurs at an ad-vanced stage of the disease and its treatment effect and prognosis are extremely poor. There is still a long way to go in scientific research of pancreatic cancer. This article describes the mechanism of ncRNAs in the occurrence, progression and drug resistance of pancreatic cancer, hoping to provide some ideas for re-searchers to find targets for the tumor detection and treatment.