高尔基体蛋白73 (Golgi protein 73, GP73)是位于顺式高尔基体膜上的糖基化跨膜蛋白, 其在肿瘤的发展进程中具有重要作用, 是肿瘤治疗的潜在靶标。目前研究表明, GP73可作为辅助诊断肝细胞癌(hepatocellular carcinoma, HCC)的血清学标志物。随着GP73的深入研究, 与GP73有关的微RNA (microRNA, miRNA)也逐渐被挖掘出来。GP73相关miRNA与多种肿瘤的发生、发展密切相关, 其中miR-212、miR-27a等miRNA能抑制HCC的侵袭及转移, GP73与miR-27b、miR-493-5p等能作为HCC患者预后的生物标志物。因此, GP73相关miRNA用于肝癌的诊治是有前景的。本文总结了GP73及其相关miRNA在肝癌发展中的作用以及机制, 希望为肝癌的机制研究和诊疗提供思路。

Golgi protein 73 (GP73) is a glycosylated transmembrane protein located in the cis-Golgi mem-brane, which plays an important role in the development of tumors and is a potential target for tumor therapy. Current studies have shown that GP73 can be used as a serological marker to assist the diagnosis of hepatocellular carcinoma (HCC). With the further study of GP73, microRNAs (miRNAs) related to GP73 have been gradually explored and found to be closely associated with the occurrence and development of various tumors. miR-212 and miR-27a can inhibit the invasion and metastasis of HCC, and GP73, miR-27b and miR-493-5p can be used as biomarkers for prognosis of HCC patients. Therefore, GP73-related miRNAs are promising targets for the diagnosis and treatment of liver cancer. Herein, the roles and mechanisms of GP73 and its related miRNAs in the development of HCC are summarized, hoping to provide ideas for the tumor pathogenesis, diagnosis and treatment.