非编码RNA (non-coding RNA, ncRNA)作为近几年研究的热点, 它们大量存在于生物体内。大多数非编码RNA不具备编码蛋白质的能力, 但是能够调控基因表达及蛋白质功能, 在各种疾病中参与复杂的信号网络并发挥着重要的功能。胰腺癌由于早期症状不明显, 一旦被发现就是晚期, 并且治疗和预后效果极差, 因此被称为癌症之王, 目前科研上也难以攻克。本文阐述了非编码RNA在胰腺癌发生、进展及耐药过程中的作用机理, 以期为科研人员寻找检测和治疗胰腺癌的靶点提供一定的思路。

Non-coding RNAs (ncRNAs), which are abundant in organisms, have been of special concern in recent years. Most ncRNAs do not encode proteins, but they play a significant role in participating complex signaling cascades in various diseases by regulating gene expression and protein functions. Pancreatic cancer is known as the king of cancer because its early symptoms are not obvious, diagnosis often occurs at an ad-vanced stage of the disease and its treatment effect and prognosis are extremely poor. There is still a long way to go in scientific research of pancreatic cancer. This article describes the mechanism of ncRNAs in the occurrence, progression and drug resistance of pancreatic cancer, hoping to provide some ideas for re-searchers to find targets for the tumor detection and treatment.