PDF(557 KB)
Clinical diagnosis and comprehensive treatment of Fournier’s gangrene: A case report and literature review
Xiangli KONG,Kai SHI,Xi ZHANG,Yan XUE,Lei HONG,Xiuhang ZHANG
PDF(557 KB)
PDF(557 KB)
Clinical diagnosis and comprehensive treatment of Fournier’s gangrene: A case report and literature review
Objective To discuss the clinical presentations, diagnosis, and treatment methods of the patients with Fournier’s gangrene, and to enhance the clinicians’ awareness of this condition. Methods The clinical data including symptoms, signs, radiological findings, and surgical outcomes of one patient with Fournier’s gangrene were collected.The relevant literatures were reviewed to summarize the clinical characteristics, diagnosis, and treatment methods for this condition. Results The patient, a 42-year-old male, was admitted because of a history of infection around the perineum, scrotum, and perianal area for 13 d. His medical history included acute myeloid leukemia for 10 months, during which the patient underwent eight chemotherapy sessions in the local hospital. The abdominal CT scan results showed thickened, dense, and turbid soft tissue in the left inguinal area. The complete blood count reuslts showed the white blood cell count was 23.99×109 L-1. The cultures of wound secretions grew the Escherichiacoli and Proteus mirabilis. The examination results showed there was necrosis of the scrotal skin and skin near the anus on the left buttock; the skin was blackened, hard, and demarcated from the surrounding normal skin with slight purulent exudation and no foul smell. The surrounding skin was significantly swollen and red; the rectal examination results showed no bleeding or fistulas. The patient underwent emergency debridement surgery on the admission day, followed by dressing changes, multiple applications of simplified negative pressure, perineal flap reconstruction, and skin grafting. The patient recovered well with normal function and had no complications. Conclusion Fournier gangrene has acute onset and rapid progression, and the clinical manifestations are non-specific. The range of infection is not consistent with the progression of the disease. The diagnosis mainly depends on intraoperative exploration. Repeated radical surgery is the main treatment. The prognosis of this disease is good, and the recurrence rate is low, although long-term follow-up is still necessary after surgery.
Fournier’s gangrene / Necrotizing fasciitis / Negative pressure treatment / Perineum / Skin transplantation / Flap reconstruction
R631
| 1 | 孔祥力, 石 凯, 薛 岩, 等. Fournier 坏疽的研究进展[J]. 中华烧伤杂志, 2020, 6(1): 70-76. |
| 2 | FOURNIER J A. Jean-Alfred Fournier 1832-1914. Gangrène foudroyante de la verge (overwhelming gangrene). Sem Med 1883[J]. Dis Colon Rectum, 1988, 31(12): 984-988. |
| 3 | ONDER C E, GURSOY K, KUSKONMAZ S M, et al. Fournier’s gangrene in a patient on dapagliflozin treatment for type 2 diabetes[J]. J Diabetes, 2019, 11(5): 348-350. |
| 4 | HONG K S, YI H J, LEE R A, et al. Prognostic factors and treatment outcomes for patients with Fournier’s gangrene: a retrospective study[J]. Int Wound J, 2017, 14(6): 1352-1358. |
| 5 | HE X F, XIANG X, ZOU Y, et al. Distinctions between Fournier’s gangrene and lower extremity necrotising fasciitis: microbiology and factors affecting mortality[J]. Int J Infect Dis, 2022, 122: 222-229. |
| 6 | HERRERA ORTIZ A F, ARáMBULA J G, DEL CASTILLO V, et al. Fournier’s gangrene with retroperitoneal extension as the first manifestation of the human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS)[J]. Cureus, 2021, 13(12): e20517. |
| 7 | KHOKHAR F, HERNANDEZ C, MAHAPATRA R. Fournier’s gangrene in an HIV-positive patient on empagliflozin for the treatment of diabetes mellitus[J]. Cureus, 2022, 14(6): e26083. |
| 8 | HOESL V, KEMPA S, PRANTL L, et al. The LRINEC score-an indicator for the course and prognosis of necrotizing fasciitis?[J]. J Clin Med, 2022, 11(13): 3583. |
| 9 | NOEGROHO B S, SIREGAR S, MUSTAFA A, et al. Validation of FGSI scores in predicting fournier gangrene in tertiary hospital[J]. Res Rep Urol, 2021, 13: 341-346. |
| 10 | SORENSEN M D, KRIEGER J N, RIVARA F P, et al. Fournier’s Gangrene: population based epidemiology and outcomes[J]. J Urol, 2009, 181(5): 2120-2126. |
| 11 | VAILLANT T A L. Clinical-epidemiological study on Fournier’s gangrene in a Luanda hospital. From January 2016 to December 2021[J]. Medisur, 2022, 20(3): 515-526. |
| 12 | CZYMEK R, FRANK P, LIMMER S, et al. Fournier’s gangrene: is the female gender a risk factor?[J]. Langenbecks Arch Surg, 2010, 395(2): 173-180. |
| 13 | GADLER T, HUEY S, HUNT K. Recognizing Fournier’s gangrene in the emergency department [J]. Adv Emerg Nurs J, 2019, 41(1): 33-38. |
| 14 | PéREZ-MORENO L E, GONZáLEZ-VELAZQUEZ V E, RODRíGUEZ-RODRíGUEZ L L, et al. Lesion length as a prognosis marker of mortality in patients with fournier’s gangrene: proposal of a new scoring system[J]. Arch Esp Urol, 2022, 75(7): 647-654. |
| 15 | CZYMEK R, HILDEBRAND P, KLEEMANN M, et al. New insights into the epidemiology and etiology of Fournier’s gangrene: a review of 33 patients [J]. Infection, 2009, 37(4): 306-312. |
| 16 | ERICA G, JOHNATAN J, JENNIFER P. Use of POCUS to support clinical diagnosis of Fournier’s gangrene[J]. Vis J Emerg Med, 2023, 31: 101664. |
| 17 | URUSHIDANI S, OKA N. A black perineal skin lesion: a sign of Fournier gangrene[J]. CMAJ, 2023, 195(28): E957. |
| 18 | WONG C H, KHIN L W, HENG K S, et al. The LRINEC (Laboratory Risk Indicator for Necrotizing Fasciitis) score: a tool for distinguishing necrotizing fasciitis from other soft tissue infections[J]. Crit Care Med, 2004, 32(7): 1535-1541. |
| 19 | MALLIKARJUNA M N, VIJAYAKUMAR A, PATIL V S, et al. Fournier’s gangrene: current practices[J]. ISRN Surg, 2012, 2012: 942437. |
| 20 | W?HLER A, SCHWAB R, GüSGEN C, et al. Diagnosis and treatment of severe fournier’s gangrene: introduction of a surgical approach, evaluation of risk factors, microbiological characteristics and review of the literature[J]. Zentralbl Chir, 2022, 147(5): 480-491. |
| 21 | ELMI A M, KUSBECI M, OSOBLE OSMAN F A. A case report of Fournier’s gangrene: imaging ultrasound and computed tomography (CT) scan[J]. Radiol Case Rep, 2022, 17(3): 959-962. |
| 22 | LEWIS G D, MAJEED M, OLANG C A, et al. Fournier’s gangrene diagnosis and treatment: a systematic review[J]. Cureus, 2021, 13(10): e18948. |
| 23 | WRóBLEWSKA M, KUZAKA B, BORKOWSKI T, et al. Fournier’s gangrene: current concepts[J]. Pol J Microbiol, 2014, 63(3): 267-273. |
| 24 | PHILEMON E O, PROMISE W I, EZIOMA A A, et al. Neonatal Fournier’s gangrene; pattern and predisposing factors in a tertiary health facility in Southern Nigeria[J]. Trop Doct, 2022, 52(1): 42-45. |
| 25 | BOWEN D, JULIEB?-JONES P, SOMANI B K. Global outcomes and lessons learned in the management of Fournier’s gangrene from high-volume centres: findings from a literature review over the last two decades[J]. World J Urol, 2022, 40(10): 2399-2410. |
| 26 | CHEN J H, LI Y B, LI D G, et al. Vacuum sealing drainage to treat Fournier’s gangrene[J]. BMC Surg, 2023, 23(1): 211. |
| 27 | CHEN S Y, FU J P, CHEN T M, et al. Reconstruction of scrotal and perineal defects in Fournier’s gangrene[J]. J Plast Reconstr Aesthet Surg, 2011, 64(4): 528-534. |
/
| 〈 |
|
〉 |