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Application of autologous platelet-rich fibrin in immediate implant placement of molar with periapical periodontitis: A case report and literature review
Kewen JIA,Yuemeng ZHU,Siyu CHEN,Minghui LI,Jiaqian YOU,Sheng CHEN,Yanmin ZHOU
PDF(1792 KB)
PDF(1792 KB)
Application of autologous platelet-rich fibrin in immediate implant placement of molar with periapical periodontitis: A case report and literature review
Objective To observe the clinical efficacy of autologous platelet-rich fibrin (PRF) application alone in immediate dental implant placement in the molars with periapical periodontitis, and to discuss the mechanism, in order to widen its clinical application and to provide the guidance for its clinical practice. Methods The clinical data of one patient who underwent immediate implant placement in the molars with periapical periodontitis using PRF as the sole material were collected. The changes in the tissues surrounding the implant were evaluated through the three-dimensional reconstruction of cone-beam CT (CBCT) and oral scan data, the therapeutic methods and outcomes of PRF treatment were analyzed combined with the relevant literatures. Results A minimally invasive extraction of the patient’s 46 diseased molar was conducted followed by the immediate implant placement. Before surgery, 30 mL of the patient’s own blood (3 tubes) was drawn, which was then placed in 10 mL glass-coated plastic tubes without anticoagulants. Three PRF were prepared with the blood by centrifuging at 3 000 r·min-1 for 10 min. These clots were used as the only filling material for the jumping gap. The postoperative CBCT and oral scan 3D reconstruction results showed that the peri-implant bone tissue was increased by 203.19 mm3, the buccal bone height was increased by 5.83 mm, and the buccal bone tissue was increased by more than 1 mm at 6 months postoperatively; after 12 months, the soft and hard tissues around the implant remained essentially stable. Conclusion The application of autologous PRF alone in immediate implant placement in the molars with periapical periodontitis achieves favorable treatment outcomes, the peri-implant bone tissue regenerates, and the peri-implant hard and soft tissues remain stable, which providing the new insights into the immediate implant treatment.
Platelet-rich fibrin / Immediate implant placement / Periapical periodontitis / Bone regeneration
R781.341
| 1 | SLAGTER K W, RAGHOEBAR G M, HENTENAAR D F M, et al. Immediate placement of single implants with or without immediate provisionalization in the maxillary aesthetic region: a 5-year comparative study[J]. J Clin Periodontol, 2021, 48(2): 272-283. |
| 2 | DE OLIVEIRA-NETO O B, LEMOS C A, BARBOSA F T,et al. Immediate dental implants placed into infected sites present a higher risk of failure than immediate dental implants placed into non-infected sites: systematic review and meta-analysis[J]. Med Oral Patol Oral Cir Bucal, 2019, 24(4): e518-e528. |
| 3 | QUIRYNEN M, VAN ASSCHE N, BOTTICELLI D. How does the timing of implant placement to extraction affect outcome?[J]. Int J Oral Maxillofac Implants, 2007, 22(): 203-223. |
| 4 | VON ARX T, H?NNI S, JENSEN S S. Correlation of bone defect dimensions with healing outcome one year after apical surgery[J]. J Endod, 2007, 33(9): 1044-1048. |
| 5 | ZUFFETTI F, CAPELLI M, GALLI F, et al. Post-extraction implant placement into infected versus non-infected sites: a multicenter retrospective clinical study[J]. Clin Implant Dent Relat Res, 2017,19(5): 833-840. |
| 6 | KAKAR A, KAKAR K, LEVENTIS M D, et al. Immediate implant placement in infected sockets: a consecutive cohort study[J]. J Lasers Med Sci, 2020, 11(2): 167-173. |
| 7 | CRESPI R, CAPPARE P, CRESPI G, et al. Dental implants placed in periodontally infected sites in humans[J]. Clin Implant Dent Relat Res, 2017, 19(1): 131-139. |
| 8 | MU?OZ-CáMARA D, GILBEL-DEL áGUILA O, PARDO-ZAMORA G, et al. Immediate post-extraction implants placed in acute periapical infected sites with immediate prosthetic provisionalization: a 1-year prospective cohort study[J]. Med Oral Patol Oral Cir Bucal, 2020, 25(6): e720-e727. |
| 9 | RITTO F G, PIMENTEL T, CANELLAS J V S,et al. Randomized double-blind clinical trial evaluation of bone healing after third molar surgery with the use of leukocyte- and platelet-rich fibrin[J]. Int J Oral Maxillofac Surg, 2019, 48(8): 1088-1093. |
| 10 | I?IK G, ?ZDEN YüCE M, KO?AK-TOPBA? N, et al. Guided bone regeneration simultaneous with implant placement using bovine-derived xenograft with and without liquid platelet-rich fibrin: a randomized controlled clinical trial[J].Clin Oral Investig,2021,25(9): 5563-5575. |
| 11 | XUAN F, LEE C U, SON J S, et al. A comparative study of the regenerative effect of sinus bone grafting with platelet-rich fibrin-mixed Bio-Oss? and commercial fibrin-mixed Bio-Oss?: an experimental study[J]. J Craniomaxillofac Surg, 2014, 42(4): e47-e50. |
| 12 | WANG J, SUN X L, LV H X, et al. Endoscope-assisted maxillary sinus floor elevation with platelet-rich fibrin grafting and simultaneous implant placement: a prospective clinical trial[J]. Int J Oral Maxillofac Implants, 2021, 36(1): 137-145. |
| 13 | LI P, ZHU H C, HUANG D H. Autogenous DDM versus bio-oss granules in GBR for immediate implantation in periodontal postextraction sites: a prospective clinical study[J]. Clin Implant Dent Relat Res, 2018, 20(6): 923-928. |
| 14 | LV H, SUN X, WANG J, et al. Flapless osteotome-mediated sinus floor elevation using platelet-rich fibrin versus lateral approach using deproteinised bovine bone mineral for residual bone height of 2-6 mm:a randomised trial[J]. Clin Oral Implants Res, 2022, 33(7): 700-712. |
| 15 | BLANCO J, CARRAL C, ARGIBAY O, et al. Implant placement in fresh extraction sockets[J]. Periodontol 2000, 2019, 79(1): 151-167. |
| 16 | ROY S, DRIGGS J, ELGHARABLY H, et al. Platelet-rich fibrin matrix improves wound angiogenesis via inducing endothelial cell proliferation[J]. Wound Repair Regen, 2011, 19(6): 753-766. |
| 17 | BLATT S, THIEM D G E, KYYAK S, et al. Possible implications for improved osteogenesis? The combination of platelet-rich fibrin with different bone substitute materials[J]. Front Bioeng Biotechnol, 2021, 9: 640053. |
| 18 | WANG X Z, ZHANG Y F, CHOUKROUN J, et al. Effects of an injectable platelet-rich fibrin on osteoblast behavior and bone tissue formation in comparison to platelet-rich plasma[J]. Platelets, 2018, 29(1): 48-55. |
| 19 | YOU J S, KIM S G, OH J S, et al. Effects of platelet-derived material (platelet-rich fibrin) on bone regeneration[J]. Implant Dent, 2019, 28(3): 244-255. |
| 20 | KARGARPOUR Z, NASIRZADE J, PANAHIPOUR L,et al. Platelet-rich fibrin increases BMP2 expression in oral fibroblasts via activation of TGF-β signaling[J]. Int J Mol Sci, 2021, 22(15): 7935. |
| 21 | SUMIDA R, MAEDA T, KAWAHARA I, et al. Platelet-rich fibrin increases the osteoprotegerin/receptor activator of nuclear factor-κB ligand ratio in osteoblasts[J]. Exp Ther Med, 2019, 18(1): 358-365. |
| 22 | PARK J Y, HONG K J, KO K A, et al. Platelet-rich fibrin combined with a particulate bone substitute versus guided bone regeneration in the damaged extraction socket: an in vivo study[J]. J Clin Periodontol, 2023, 50(3): 358-367. |
| 23 | ELBRASHY A, OSMAN A H, SHAWKY M, et al. Immediate implant placement with platelet rich fibrin as space filling material versus deproteinized bovine bone in maxillary premolars: a randomized clinical trial[J]. Clin Implant Dent Relat Res, 2022, 24(3): 320-328. |
| 24 | MARSHALL G, CANULLO L, LOGAN R M, et al. Histopathological and microbiological findings associated with retrograde peri-implantitis of extra-radicular endodontic origin: a systematic and critical review[J]. Int J Oral Maxillofac Surg, 2019, 48(11): 1475-1484. |
| 25 | RODRíGUEZ SáNCHEZ F, VERSPECHT T, CASTRO A B, et al. Antimicrobial mechanisms of leucocyte- and platelet rich fibrin exudate against planktonic porphyromonas gingivalis and within multi-species biofilm: a pilot study[J]. Front Cell Infect Microbiol, 2021, 11: 722499. |
| 26 | DRAGO L, BORTOLIN M, VASSENA C, et al. Antimicrobial activity of pure platelet-rich plasma against microorganisms isolated from oral cavity[J]. BMC Microbiol, 2013, 13: 47. |
| 27 | SCHULDT L, BI J R, OWEN G, et al. Decontamination of rough implant surfaces colonized by multispecies oral biofilm by application of leukocyte- and platelet-rich fibrin[J].J Periodontol,2021,92(6):875-885. |
| 28 | ZHANG J L, YIN C C, ZHAO Q, et al. Anti-inflammation effects of injectable platelet-rich fibrin via macrophages and dendritic cells[J]. J Biomed Mater Res Part A, 2020, 108(1): 61-68. |
| 29 | KARGARPOUR Z, NASIRZADE J, PANAHIPOUR L, et al. Liquid PRF reduces the inflammatory response and osteoclastogenesis in murine macrophages[J]. Front Immunol, 2021, 12: 636427. |
| 30 | NASIRZADE J, KARGARPOUR Z, HASANNIA S, et al. Platelet-rich fibrin elicits an anti-inflammatory response in macrophages in vitro [J]. J Periodontol, 2020, 91(2): 244-252. |
| 31 | SORDI M B, PANAHIPOUR L, KARGARPOUR Z, et al. Platelet-rich fibrin reduces IL-1β release from macrophages undergoing pyroptosis[J]. Int J Mol Sci, 2022, 23(15): 8306. |
| 32 | OH S L, JI C, AZAD S. Free gingival grafts for implants exhibiting a lack of keratinized mucosa: extended follow-up of a randomized controlled trial[J]. J Clin Periodontol, 2020, 47(6): 777-785. |
| 33 | SHAH R, GOWDA T M, THOMAS R, et al. Biological activation of bone grafts using injectable platelet-rich fibrin[J]. J Prosthet Dent, 2019, 121(3): 391-393. |
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