Objective To investigate the clinical characteristics of women with abnormal uterine bleeding （AUB） in sub-plateau regions and analyze the factors affecting their treatment methods. Methods AUB patients who were hospitalized from Jan 1， 2018 to Dec 31， 2022， in a sub-plateau region （Yongping County People’s Hospital of Yunnan Province）with an average altitude of 1 620 meters were selected. The general clinical characteristics of the patients were summarized， and patients were classified into two categories （with or without uterine structural lesion） and nine subtypes （PALM-COEIN） according to the FIGO recommended etiological classification guidelines. Then the patients were divided into groups based on the presence or absence of uterine structural lesions， ethnic group （Han and minority）， conservative drug treatment and surgical treatment groups， blood transfusion and non-blood transfusion groups. Binary Logistic regression analysis was used to identify factors affecting treatment methods. Results A total of 481 AUB patients enrolled， and the delayed consultation rate was as high as 80.46%， and the proportion of overweight and obese patients was 49.90%， which was higher than the average level among Chinese women. The main cause was AUB-O （AUB-ovulatory dysfunction）， accounting for 78.59% of cases，the proportion of patients with delayed medical treatment was higher than those without delayed medical treatment （82.17% vs. 74.47%）. Patients who received blood transfusion were significantly younger， had lower hemoglobin （HGB） levels， fewer pregnancies， and lower BMI compared to those in the non-blood transfusion group （P<0.05）. Univariate analysis showed that the surgical treatment group had older age， longer onset time， higher HGB levels， more pregnancies and deliveries， higher BMI， a higher proportion of Han ethnicity patients， lower rates of non-blood transfusion， higher rates of hypertension， and more uterine structural lesions compared to the conservative drug treatment group. Multivariate regression analysis revealed that blood transfusion treatment reduced the probability of surgical treatment. Age and uterine structural lesions were risk factors for requiring surgical treatment， for each additional year of age， the risk of undergoing surgical treatment increased by 10%. The risk of requiring surgical treatment for patients with uterine structural lesions was 2.987 times higher than for those without. Conclusion AUB patients in this sub-plateau regions have a high rate of delayed consultation and a high proportion of overweight and obesity， with AUB-O being the primary cause. Older age and the presence of uterine structural lesions were risk factors for requiring surgical treatment.