Sediment accommodation space has many controlling factors and is difficult to analyze quantitively. To address this issue, we designate a “total accommodation space”, which is the sum of all accommodation spaces during the deposition process, and summarize various controlling factors into three main factors: initial topography, global (absolute) sea level change, and total settlement. Based on the principle that the volume of the total accommodation space equals its fill volume, a quantitative relationship between the initial topography, global sea level change, total settlement/sedimentary thickness, and water depth is established. The influence of the main controlling factors on the stratum structure is analyzed, and a method for quantitative analysis of total accommodation space is proposed. This method can be applied to not only calculate the total settlement—thus reducing the difficulty in recovery and characterization of 3D sedimentary parameters, and ensuring the total accommodation space provided by sedimentary forward and inversion modeling is in line with expectations—but also establish the quantitative relationship between the main controlling factors and quickly recover the reasonable stratigraphic sedimentary parameters, which is conducive to establishing a sedimentary model. This study not only provides a more intuitive understanding of the quantitative relationship between the main controlling factors of accommodation space, but also lays a foundation for the quantitative study of effective accommodation spaces.